Evidence map›Paper›PMID 31005203›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2019

Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies.

Zhiyong Yang, Yu Chang, Kristy K Brock, Guillaume Cazoulat, Eugene J Koay, Albert C Koong, Joseph M Herman, Peter C Park, Falk Poenisch, Qin Li and 8 more

Abstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Adaptive proton therapy.Physics in medicine and biology · 2021
    Review
  6. Robust Angle Selection in Particle Therapy.Frontiers in oncology · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Zhiyong YangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Yu ChangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kristy K BrockDepartment of Image Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Guillaume CazoulatDepartment of Image Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Eugene J KoayDivision of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States.
Albert C KoongDivision of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States.
Joseph M HermanDivision of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States.
Peter C ParkDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Falk PoenischDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Qin LiCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kunyu YangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gang WuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Brian AndersonDepartment of Image Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Andrea N OhrtDepartment of Image Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Yupeng LiDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
X Ronald ZhuDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Xiaodong ZhangDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States.
Heng LiDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States. Electronic address: hengli@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USUnion Hospital · CN

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

purposeTo evaluate the effect of setup uncertainties including uncertainties between different breath holds (BH) and inter-fractional anatomical changes under CT-guided BH with intensity-modulated proton therapy (IMPT) in patients with liver cancer. METHODS AND MATERIALS: This retrospective study considered 17 patients with liver tumors who underwent feedback-guided BH (FGBH) IMRT treatment with daily CT-on-rail imaging. Planning CT images were acquired at simulation using FGBH, and FGBH CT-on-rail images were also acquired prior to each treatment. Selective robust IMPT plans were generated using planning CT and re-calculated on each daily CT-on-rail image. Subsequently, the fractional doses were deformed and accumulated onto the planning CT according to the deformable image registration between daily and planning CTs. The doses to the target and organs at risk (OARs) were compared between IMRT, planned IMPT, and accumulated IMPT doses.

resultsFor IMPT plans, the mean of D

conclusionsIMPT with FGBH and CT-on-rail guidance is a robust treatment approach for liver tumor cases.

Indexed as

Breath HoldingFemaleHumansLiver NeoplasmsMaleProton TherapyRadiotherapy DosageRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedRetrospective StudiesTomography, X-Ray ComputedAccumulated doseIntensity-modulated proton therapyLiver cancer

Identifiers

PMID31005203
PMCPMC12131267
OpenAlexW2911643031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.