Evidence map›Paper›PMID 31004740›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019

Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation.

Philip A Spechler, Bader Chaarani, Catherine Orr, Scott Mackey, Stephen T Higgins, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan and 19 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  7. The ABCD stop signal data: Response to Bissett et al.Developmental cognitive neuroscience · 2022
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  12. Editorial: Linking Emotional and Behavioral Dysregulation in Adolescents to Regulatory Cortex.Journal of the American Academy of Child and Adolescent Psychiatry · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 17 institutions in 7 countries.

Philip A SpechlerUniversity of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington. Electronic address: philip.spechler@uvm.edu.
Bader ChaaraniUniversity of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.
Catherine OrrUniversity of Vermont, Burlington.
Scott MackeyUniversity of Vermont, Burlington.
Stephen T HigginsUniversity of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.
Tobias BanaschewskiCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Arun L W BokdeSchool of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Uli BrombergUniversity Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Christian BüchelUniversity Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Erin Burke QuinlanCentre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Patricia J ConrodUniversite de Montreal, CHU Ste Justine Hospital, Canada.
Sylvane DesrivièresCentre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Herta FlorCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; School of Social Sciences, University of Mannheim, Mannheim, Germany.
Vincent FrouinNeuroSpin, CEA, Université Paris-Saclay, France.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, UK.
Andreas HeinzCampus Charité Mitte, Charité, Universitätsmedizin Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud - University Paris Saclay, France.
Frauke NeesCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, France.
Luise PoustkaUniversity Medical Centre Göttingen, Germany, and the Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Austria.
Juliane H FröhnerTechnische Universität Dresden, Germany.
Michael N SmolkaTechnische Universität Dresden, Germany.
Henrik WalterCampus Charité Mitte, Charité, Universitätsmedizin Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Hugh GaravanUniversity of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.
Robert R AlthoffUniversity of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.
IMAGEN Consortium
University of Vermont · USKing's College London · GBCharité - Universitätsmedizin Berlin · DETrinity College Dublin · IECentral Institute of Mental Health · DETU Dresden · DEUniversity Medical Center Hamburg-Eppendorf · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRMedical University of Vienna · ATPhysikalisch-Technische Bundesanstalt · DEUniversité Paris-Saclay · FRUniversity of Nottingham · GBCentre Hospitalier Universitaire Sainte-Justine · CANeuroimaging and Psychiatry · FRUniversität Hamburg · DEUniversity Hospital Heidelberg · DEUniversity of Mannheim · DE

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SIGMON, STACEY C · 2013 to 2022
$21.3M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
Medical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1MRF_ MRF-058-0004-RG-DESRINIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM103644NIMH NIH HHS R01 MH085772
6 · The paper itself

Abstract

objectiveTo characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype.

methodAdolescents aged 14 years from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties ("dysregulated"; n = 233) who were compared to a matched sample from a low symptom class (controls, n = 233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three functional magnetic resonance imaging (fMRI) tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation.

resultsWhole-brain differences were found in the right orbitofrontal cortex (R.OFC; p < .05; k = 48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F

conclusionA large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to those of controls. These findings suggest a neurobiological marker of dysregulation and highlight the role of the R.OFC in impaired emotional and behavioral control.

Indexed as

Adolescent BehaviorEmotionsAdolescentCase-Control StudiesFemaleGray MatterHumansLatent Class AnalysisMagnetic Resonance ImagingMaleModels, PsychologicalNeuroimagingOrgan SizePrefrontal Cortexadolescencedysregulationorbitofrontal cortexSDQVBM

Identifiers

PMID31004740
OpenAlexW2938980179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.