Evidence map›Paper›PMID 31004724›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2019

The silent epidemic of chronic pain in older adults.

Anthony F Domenichiello, Christopher E Ramsden

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 214 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 7 pooled it
29.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07287501 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Pain Science Education Combined With Exercise in Older Adults With Chronic Pain

TypeinterventionalSponsorUniversity of SalamancaRan2025 to 2026Enrolled100ConditionsChronic PainArmsMulticomponent training combined with Pain Science Education during 8 weeks, Multicomponent training, Multicomponent training combined with Pain Science Education during 32 weeks
NCT07421674 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Application Research of Hydromorphinone Sustained-release Tablets in the Treatment of Elderly Patients With Cancer Pain Accompanied by Renal Insufficiency

Typeobservational_patient_registrySponsorTaian Cancer HospitalRan2026 to 2028Enrolled62ConditionsCancer Pain, Renal Insufficiency Chronic, Hydromorphone Use
3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 7 syntheses or guidelines pooled it, 400 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  5. Effectiveness of pharmacological and non-pharmacological therapy on pain intensity and disability in older people with chronic nonspecific low back pain: a systematic review with meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Pooled it
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  8. Trial
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  17. Observational
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154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Anthony F DomenichielloLipid Peroxidation Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.
Christopher E RamsdenLipid Peroxidation Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, USA. Electronic address: ramsdence@mail.nih.gov.
National Institute on Aging · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

The roles of lipid mediators in inflammation, pain, and neuro-degenerationZIAAG000453 · NIA · NATIONAL INSTITUTE ON AGING · PI RAMSDEN, CHRISTOPHER · 2017 to 2025
$35.1M
Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are underrepresented in clinical trials testing treatments for chronic pain, the potential impacts of polypharmacy and frailty on reported outcomes and side effect profiles are largely unknown. Thus, for current treatments, providers and patients must balance anticipated benefits of pain reduction with the known and unknown risks of treatment. Chronic pain is also a risk factor for premature death as well as accelerated cognitive decline, suggesting potential shared mechanisms between persistent pain (or its treatment) and dementia. Cognitive decline and dementia may also impact pain perception and the ability to report pain, complicating treatment decisions. Associations between persistent pain and the risks of premature death and accelerated cognitive decline make estimates for chronic pain in these populations particularly challenging. Future research is needed to improve estimates for chronic pain in older adults, to elucidate underlying mechanisms of pain with aging, and to develop and advance safer, more effective treatment options for chronic pain in older adults.

Indexed as

AgedAge FactorsChronic PainDementiaEpidemicsHumansPain ManagementQuality of LifeRisk FactorsAge-related diseaseAgingChronic painCognitiveDementia

Identifiers

PMID31004724
PMCPMC6538291
OpenAlexW2939881801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.