Evidence map›Paper›PMID 31004614›Full record

ArticleThe Journal of allergy and clinical immunology2019

Maternal triacylglycerol signature and risk of food allergy in offspring.

Xiumei Hong, Liming Liang, Qi Sun, Corinne A Keet, Hui-Ju Tsai, Yuelong Ji, Guoying Wang, Hongkai Ji, Clary Clish, Colleen Pearson and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Fetal lipidome and incident risk of food allergy: A prospective birth cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Association Between Folate Metabolites and the Development of Food Allergy in Children.The journal of allergy and clinical immunology. In practice · 2020
    Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Xiumei HongDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md. Electronic address: xhong3@jhu.edu.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston Mass.
Qi SunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Mass; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Corinne A KeetDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Md.
Hui-Ju TsaiDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Institute of Population Health Sciences, National Health Research Institute, Zhunan, Taiwan.
Yuelong JiDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Guoying WangDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Clary ClishBroad Institute of MIT and Harvard University, Cambridge, Mass.
Colleen PearsonDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Mass.
You WangDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Robert A WoodDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Md.
Frank B HuDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Mass; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Xiaobin WangDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Md.
Johns Hopkins University · USBrigham and Women's Hospital · USHarvard University · USJohns Hopkins Medicine · USBoston University · USNational Health Research Institutes · TW

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Boston University Clinical and Translational Science Institute - U ProgramU54TR001012 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2014 to 2014
$3.9M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Post Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3M
Molecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562k
Prenatal Multi-Level Stressors and Alterations in Maternal and Fetal EpigenomesR21HD085556 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SURKAN, PAMELA J, WANG, XIAOBIN · 2016 to 2017
$449k
Establishing Precursors of Food Allergy in NewbornsR21AI079872 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2008 to 2009
$447k
Maternal Stress and Preterm Birth: Role of Genome and EpigenomeR03HD096136 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HONG, XIUMEI · 2018 to 2019
$164k
NCATS NIH HHS U54 TR001012NIAID NIH HHS R21 AI079872NIAID NIH HHS U01 AI090727NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R03 HD096136NICHD NIH HHS R21 HD085556NIDDK NIH HHS P30 DK040561NIEHS NIH HHS R21 ES011666
6 · The paper itself

Abstract

backgroundThe prevalence of IgE-mediated food allergy (FA) is increasing worldwide, but the underlying mechanisms are poorly understood.

objectiveWe sought to examine the role of maternal lipidomic profiles in risk of FA development in offspring and to investigate the potential modification effects by timing of first solid-food introduction.

methodsThis report included 1068 mother-child dyads from the Boston Birth Cohort. Maternal lipid metabolites in plasma were assessed by using liquid chromatography tandem mass spectrometry. Food sensitization (FS) was defined as a specific IgE level of 0.35 kU/L or greater to any of the 8 common food allergens determined by using ImmunoCAP. FA was defined based on FS, clinical symptoms, and food avoidance. Logistic regression was applied to analyze associations between maternal metabolites and risk of FS and FA in offspring and to explore potential effect modifications.

resultsOf the 1068 children, 411 had FS, and 132 had FA. Among the 209 metabolites, maternal triacylglycerols (TAGs) of shorter carbon chains and fewer double bonds were associated with greater risk of FA, whereas TAGs of longer carbon chains and more double bonds were significantly associated with lower risk of FA in offspring. These associations were stronger in children with delayed solid-food introduction (≥7 months of age) than those with earlier solid-food introduction (P = .010 for interaction between the maternal TAG score and timing of solid-food introduction). No significant association was found for FS.

conclusionThis is the first study to demonstrate a link between maternal TAGs and risk of FA in offspring and potential risk modification by timing of solid-food introduction.

Indexed as

Prenatal Exposure Delayed EffectsAdultAllergensBostonBreast FeedingChildChild, PreschoolFemaleFood HypersensitivityHumansImmunoglobulin EMaleMaternal-Fetal ExchangePregnancyRisk FactorsTriglyceridesAllergensImmunoglobulin ETriglyceridesFood allergylipidomicstiming of first solid-food introductiontriacylglycerol

Identifiers

PMID31004614
PMCPMC6941352
OpenAlexW2936924903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.