ArticleFEMS microbiology letters2019
In silico prediction and characterisation of secondary metabolite clusters in the plant pathogenic fungus Verticillium dahliae.
Article in FEMS microbiology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Interspecies hybridization as a route of accessory chromosome origin in fungal pathogens.mBio · 2026Article
- The adapt-to-nutrient NRPS-like secondary metabolite gene cluster facilitates Verticillium dahliae adaptation to different nutrient environments.PLoS genetics · 2026Article
- Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution.Nature communications · 2025Article
- Genomic insights intoFrontiers in microbiology · 2024Review
- Genome-Based Analysis ofBiology · 2022Article
- A polyketide synthase from Verticillium dahliae modulates melanin biosynthesis and hyphal growth to promote virulence.BMC biology · 2022Article
- Robust Profiling of Cytochrome P450s (P450ome) in NotableLife (Basel, Switzerland) · 2022Article
- A Secondary Metabolism Pathway Involved in the Production of a Putative Toxin Is Expressed at Early Stage ofFrontiers in plant science · 2022Article
- Article
- Opportunities and Challenges in Studies of Host-Pathogen Interactions and Management ofPlants (Basel, Switzerland) · 2020Review
- Genome compartmentalization predates species divergence in the plant pathogen genus Zymoseptoria.BMC genomics · 2020Article
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6 authors.
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Abstract
Fungi are renowned producers of natural compounds, also known as secondary metabolites (SMs) that display a wide array of biological activities. Typically, the genes that are involved in the biosynthesis of SMs are located in close proximity to each other in so-called secondary metabolite clusters. Many plant-pathogenic fungi secrete SMs during infection in order to promote disease establishment, for instance as cytocoxic compounds. Verticillium dahliae is a notorious plant pathogen that can infect over 200 host plants worldwide. However, the SM repertoire of this vascular pathogen remains mostly uncharted. To unravel the potential of V. dahliae to produce SMs, we performed in silico predictions and in-depth analyses of its secondary metabolite clusters. Using distinctive traits of gene clusters and the conserved signatures of core genes 25 potential SM gene clusters were identified. Subsequently, phylogenetic and comparative genomics analyses were performed, revealing that two putative siderophores, ferricrocin and TAFC, DHN-melanin and fujikurin may belong to the SM repertoire of V. dahliae.
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