SynthesisJournal of behavioral medicine2019
Cognitive behavioral therapy for primary care depression and anxiety: a secondary meta-analytic review using robust variance estimation in meta-regression.
Synthesis in Journal of behavioral medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 11 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Evaluating the Efficacy of Telehealth-Based Treatments for Depression in Adults: A Rapid Review and Meta-Analysis.Journal of occupational rehabilitation · 2025Pooled it
- Determining the impact of mobile-based self-care applications on reducing anxiety in healthcare providers: a systematic review.BMC medical informatics and decision making · 2025Pooled it
- Do the effects of internet-delivered cognitive-behavioral therapy (i-CBT) last after a year and beyond? A meta-analysis of 154 randomized controlled trials (RCTs).Clinical psychology review · 2024Pooled it
- Effects of an exercise intervention on maternal depression, anxiety, and fatigue: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- The Depression Prevalence in Chinese Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.Actas espanolas de psiquiatria · 2023Pooled it
- The Effectiveness of Cognitive Behavioral Therapy for Depression Among Individuals with Diabetes: a Systematic Review and Meta-Analysis.Current diabetes reports · 2023Pooled it
- Anxiety Screening: Evidence Report and Systematic Review for the US Preventive Services Task Force.JAMA · 2023Pooled it
- Pooled it
- Pooled it
- Winning The Game Against Depression: A Systematic Review of Video Games for the Treatment of Depressive Disorders.Current psychiatry reports · 2022Pooled it
- Physical exercise interventions for perinatal depression symptoms in women: A systematic review and meta-analysis.Frontiers in psychology · 2022Pooled it
- Primary Care Physician Adherence to Telepsychiatry Recommendations: Intermediate Outcomes from a Randomized Clinical Trial.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2022Trial
- Development of a cognitive bias modification intervention for anxiety disorders in primary care.The British journal of clinical psychology · 2022Trial
- Trial
- Effectiveness of Collaborative, Trauma-Informed Care on Depression Outcomes in Primary Care: A Cluster Randomized Control Trial in Chile.Annals of family medicineTrial
- Sleep quality and anxiety among final-year medical interns during a family medicine clerkship: a cross-sectional study with implications for primary care training.BMC primary care · 2026Article
- Specialist Rehabilitation Providers' Experiences With an Online Self-Compassion Course: Reflexive Thematic Analysis.JMIR rehabilitation and assistive technologies · 2026Article
- The Impact of Government-Funded Brief Psychological Interventions on Mental Health: A Longitudinal Evaluation of the Italian "Psychological Bonus" Policy.Community mental health journal · 2026Article
- Mediating Effect of Anxiety/Depression Between Nomophobia and Disordered Eating Among Lebanese Young Adults: A Cross-Sectional Study.Health science reports · 2026Article
- Network analysis of anxiety, depression, stress symptoms and psychological resilience in shift nurses.BMC psychology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive-behavioral therapy (CBT) is well supported for treating depressive and anxiety disorders. Trials of CBT for anxiety and depression in primary care have increased over the past decade, yet only one meta-analysis, published in 2015, examined this topic and the scope of that review is relatively narrow. This study conducted a systematic review and meta-analysis of primary care based CBT for depression and anxiety. A search of seven electronic databases, six professional websites, and reference lists from articles meeting inclusion criteria was conducted for studies published between 1900 and November 2018. Fifty-seven eligible studies (including 10,701 participants; 221 effect sizes) of randomized controlled trials were eligible and included for meta-analysis using robust variance estimation in meta-regression. Outcome indicators were depression and anxiety measures. An overall significant treatment effect, d = 0.400, 95% CI (0.235, 0.566), p < 0.001, of CBT for depression and anxiety disorders in primary care was identified. Subgroup analyses indicated significant treatment effect for: (1) depressive (d = 0.425, p < 0.001) and anxiety (d = 0.393, p < 0.01) outcomes, (2) studies conducted inside primary care (d = 0.412, p < 0.001), (3) studies using individual-based CBT (d = 0.412, p < 0.001), (4) studies without primary care physician involvement (d = 0.395, p < 0.001), and (5) studies using both tele-health (d = 0.563, p < 0.001) and in-person CBT (d = 0.363, p < 0.001). The percentage of White participants, treatment composition (CBT only versus CBT + other approaches), and treatment duration were significant moderators. Implications for clinical practice are discussed based on both moderator and subgroup analysis results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.