ArticleJournal of biomechanical engineering2019
On the simulation of mitral valve function in health, disease, and treatment.
Article in Journal of biomechanical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 59 citations in OpenAlex.
- Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve Closure.Annals of biomedical engineering · 2026Article
- Automatic 4D mitral valve segmentation from transesophageal echocardiography: a semi-supervised learning approach.Medical & biological engineering & computing · 2026Article
- A Parametric Model of the Mitral Valve for Finite Element Patient-Specific Simulations.Bioengineering (Basel, Switzerland) · 2026Article
- Article
- Leaflet Lengths and Commissural Dimensions as the Primary Determinants of Orifice Area in Mitral Regurgitation: A Sobol Sensitivity Analysis.Bioengineering (Basel, Switzerland) · 2026Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- Transcatheter measurement of mitral valve coaptation pressure: A proof-of-concept study using animal models.Bioengineering & translational medicine · 2026Article
- A noninvasive method for determining elastic parameters of valve tissue using physics-informed neural networks.Acta biomaterialia · 2025Article
- HETEROGENEOUS PERIDYNAMIC NEURAL OPERATORS: DISCOVER BIOTISSUE CONSTITUTIVE LAW AND MICROSTRUCTURE FROM DIGITAL IMAGE CORRELATION MEASUREMENTS.Foundations of data science (Springfield, Mo.) · 2025Article
- Article
- FEBio FINESSE: An Open-Source Finite Element Simulation Approach to Estimate In Vivo Heart Valve Strains Using Shape Enforcement.Annals of biomedical engineering · 2025Article
- Interactive Effects Between Papillary Muscle Approximation and Ring Annuloplasty to Repair Functional Mitral Regurgitation in Enlarged Ventricles.Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference) · 2025Article
- Exploring coronary microvascular dysfunction from functional impairment and structural damage.Frontiers in cardiovascular medicine · 2025Review
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Characterisation of global and regional mitral annular strains in an acute porcine model.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- The role of computational methods in cardiovascular medicine: a narrative review.Translational pediatrics · 2024Review
- An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets.Journal of biomechanics · 2023Article
- Computational Modeling of the Subject-Specific Effects of Annuloplasty Ring Sizing on the Mitral Valve to Repair Functional Mitral Regurgitation.Annals of biomedical engineering · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitral valve (MV) is the heart valve that regulates blood ?ow between the left atrium and left ventricle (LV). In situations where the MV fails to fully cover the left atrioventricular ori?ce during systole, the resulting regurgitation causes pulmonary congestion, leading to heart failure and/or stroke. The causes of MV insuf?ciency can be either primary (e.g. myxomatous degeneration) where the valvular tissue is organically diseased, or secondary (typically inducded by ischemic cardiomyopathy) termed ischemic mitral regurgitation (IMR), is brought on by adverse LV remodeling. IMR is present in up to 40% of patients and more than doubles the probability of cardiovascular morbidity after 3.5 years. There is now agreement that adjunctive procedures are required to treat IMR caused by lea?et tethering. However, there is no consensus regarding the best procedure. Multicenter registries and randomized trials would be necessary to prove which procedure is superior. Given the number of proposed procedures and the complexity and duration of such studies, it is highly unlikely that IMR procedure optimization will be achieved by prospective clinical trials. There is thus an urgent need for cell and tissue physiologically based quantitative assessments of MV function to better design surgical solutions and associated therapies. Novel computational approaches directed towards optimized surgical repair procedures can substantially reduce the need for such trial-and-error approaches. We present the details of our MV modeling techniques, with an emphasis on what is known and investigated at various length scales.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.