ArticleScientific reports2019
Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- A Systematic Review on the Viruses ofTropical medicine and infectious disease · 2023Review
- Metagenomic Insight into the Microbiome and Virome Associated withInfectious disease reports · 2023Article
- Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics.PLoS pathogens · 2023Review
- Composition and global distribution of the mosquito virome - A comprehensive database of insect-specific viruses.One health (Amsterdam, Netherlands) · 2023Article
- Review
- Complete genome ofmicroPublication biology · 2023Article
- Factors enhancing the transmission of mosquito-borne arboviruses in Africa.Virusdisease · 2022Review
- Local-scale virome depiction in Medellín, Colombia, supports significant differences between Aedes aegypti and Aedes albopictus.PloS one · 2022Article
- Characterization of the virome associated with Haemagogus mosquitoes in Trinidad, West Indies.Scientific reports · 2021Article
- Negeviruses Reduce Replication of Alphaviruses during Coinfection.Journal of virology · 2021Article
- Review
- Comprehensive Ecological and Geographic Characterization of Eukaryotic and Prokaryotic Microbiomes in AfricanFrontiers in microbiology · 2021Article
- Exploiting insect-specific viruses as a novel strategy to control vector-borne disease.Current opinion in insect science · 2020Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquitoes are colonized by a little-studied natural virome. Like the bacterial microbiome, the virome also probably influences the biology and immunity of mosquito vector populations, but tractable experimental models are lacking. We recently discovered two novel viruses in the virome of wild Anopheles and in colonies of the malaria vector Anopheles coluzzii: Anopheles C virus and Anopheles cypovirus. Here, we describe biological interactions between these two viruses and An. coluzzii mosquitoes. Viral abundance varies reproducibly during mosquito development. DNA forms of these viruses were not detected, and thus viral persistence is likely based on vertical transmission of RNA genomes. At least Anopheles C virus is vertically transmitted by an intraembryonic route. Relative abundance of the two viruses is inversely correlated in individual mosquitoes. One possible mechanism for this could be interactions with host immunity, and functional genomic analysis indicated differential influence of at least the Toll and JAK/STAT immune signaling pathways upon the viruses. The nonrandom distributions and interactions with host immunity suggest that these and other members of the natural virome may constitute a source of unrecognized heterogeneity in mosquito vector populations.
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