Evidence map›Paper›PMID 31004094›Full record

ArticleScientific reports2019

Studying the rigidity of red blood cells induced by Plasmodium falciparum infection.

Apurba Paul, Ghania Ramdani, Utpal Tatu, Gordon Langsley, Vasant Natarajan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Tropical medicine and infectious disease · 2023
    Review
  4. Review
  5. Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.Frontiers in cellular and infection microbiology · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Apurba PaulDepartment of Physics, Indian Institute of Science, Bangalore, 560012, India.ORCID http://orcid.org/0000-0002-2187-7421
Ghania RamdaniInserm U1016, CNRS UMR8104, Cochin Institute, Paris, 75014, France.
Utpal TatuDepartment of Biochemistry, Indian Institute of Science, Bangalore, 560012, India.
Gordon LangsleyInserm U1016, CNRS UMR8104, Cochin Institute, Paris, 75014, France.ORCID http://orcid.org/0000-0001-6600-6286
Vasant NatarajanDepartment of Physics, Indian Institute of Science, Bangalore, 560012, India. vasant@physics.iisc.ernet.in.
Indian Institute of Science Bangalore · INCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity.

Indexed as

ErythrocytesBystander EffectHumansMalaria, FalciparumOptical TweezersPlasmodium falciparum

Identifiers

PMID31004094
PMCPMC6474899
OpenAlexW2935693326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.