Evidence map›Paper›PMID 31004027›Full record

ArticleHaematologica2020

Ttc7a regulates hematopoietic stem cell functions while controlling the stress-induced response.

Claire Leveau, Tania Gajardo, Marie-Thérèse El-Daher, Nicolas Cagnard, Alain Fischer, Geneviève de Saint Basile, Fernando E Sepulveda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Regulation of stress-induced hematopoiesis.Current opinion in hematology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Claire LeveauLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR 1163, Imagine Institute, Paris.
Tania GajardoLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR 1163, Imagine Institute, Paris.
Marie-Thérèse El-DaherLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR 1163, Imagine Institute, Paris.
Nicolas CagnardUniversité Paris Descartes -Sorbonne Paris Cité, Imagine Institute, Paris.
Alain FischerUniversité Paris Descartes -Sorbonne Paris Cité, Imagine Institute, Paris.
Geneviève de Saint BasileLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR 1163, Imagine Institute, Paris genevieve.de-saint-basile@inserm.fr fernando.sepulveda@inserm.fr.
Fernando E SepulvedaLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR 1163, Imagine Institute, Paris genevieve.de-saint-basile@inserm.fr fernando.sepulveda@inserm.fr.
Institut des Maladies Génétiques Imagine · FRSorbonne Paris Cité · FRUniversité Paris Cité · FRCentre de Référence Déficits Immunitaires Héréditaires · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular machinery that regulates the balance between self-renewal and differentiation properties of hematopoietic stem cells (HSC) has yet to be characterized in detail. Here we found that the tetratricopeptide repeat domain 7 A (Ttc7a) protein, a putative scaffold protein expressed by HSC, acts as an intrinsic regulator of the proliferative response and the self-renewal potential of murine HSC

Indexed as

Hematopoietic Stem CellsProteinsAnimalsCell DifferentiationCell ProliferationMiceProteins

Identifiers

PMID31004027
PMCPMC6939534
OpenAlexW2937146521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.