Evidence map›Paper›PMID 31004015›Full record

SynthesisHaematologica2020

Use of immunosuppressive therapy for management of myelodysplastic syndromes: a systematic review and meta-analysis.

Maximilian Stahl, Jan Philipp Bewersdorf, Smith Giri, Rong Wang, Amer M Zeidan

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Review
  8. Article
  9. Treatment of Anemia in Lower-Risk Myelodysplastic Syndrome.Current treatment options in oncology · 2024
    Review
  10. Article
  11. Bone marrow CD3European journal of haematology · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. There won'T be blood.Nature immunology · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Maximilian StahlLeukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Jan Philipp BewersdorfDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT.
Smith GiriDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT.
Rong WangCancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, CT.
Amer M ZeidanDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT amer.zeidan@yale.edu.
Yale Cancer Center · USYale University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016359
6 · The paper itself

Abstract

Immunosuppressive therapy (IST) is one therapy option for treatment of patients with lower-risk myelodysplastic syndromes (MDS). However, the use of several different immunosuppressive regimens, the lack of high-quality studies, and the absence of validated predictive biomarkers pose important challenges. We conducted a systematic review and meta-analysis according to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and searched MEDLINE

Indexed as

Myelodysplastic SyndromesAntilymphocyte SerumHumansImmunosuppression TherapyImmunosuppressive AgentsProspective StudiesAntilymphocyte SerumImmunosuppressive Agents

Identifiers

PMID31004015
PMCPMC6939518
OpenAlexW2937938515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.