Evidence map›Paper›PMID 31004009›Full record

ArticleRNA (New York, N.Y.)2019

Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development.

Mitzli X Velasco, Adam Kosti, Gabriela D A Guardia, Marcia C Santos, Allison Tegge, Mei Qiao, Bruna R S Correa, Greco Hernández, Erzsebet Kokovay, Pedro A F Galante and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026
    Review
  2. Article
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  4. Article
  5. Review
  6. Review
  7. Article
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  10. RNA-binding protein signaling in adult neurogenesis.Frontiers in cell and developmental biology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. miR-137: A Novel Therapeutic Target for Human Glioma.Molecular therapy. Nucleic acids · 2020
    Review
  19. RNA-binding proteins in tumor progression.Journal of hematology & oncology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Mitzli X Velasco *Greheey Children's Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Adam Kosti *Greheey Children's Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Gabriela D A Guardia *Centro de Oncologia Molecular-Hospital Sírio-Libanês, São Paulo 01308-050, Brazil.
Marcia C SantosGreheey Children's Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Allison TeggeDepartment of Statistics, Virginia Tech, Blacksburg, Virginia 14080, USA.
Mei QiaoGreheey Children's Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Bruna R S CorreaGreheey Children's Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Greco HernándezTranslation and Cancer Laboratory, Unit of Biomedical Research on Cancer, National Institute of Cancer (INCan), Mexico City 14080, Mexico.
Erzsebet KokovayDepartment of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Pedro A F GalanteCentro de Oncologia Molecular-Hospital Sírio-Libanês, São Paulo 01308-050, Brazil.
Luiz O F PenalvaGreheey Children's Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
The University of Texas Health Science Center at San Antonio · USHospital Sírio-Libanês · BRInstituto Nacional de Cancerología · MXVirginia Tech · US

Funding

Computational Methods for Deep Sequencing Based RBP Binding Motif CharacterizatioR01HG006015 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PENALVA, LUIZ OTAVIO, SMITH, ANDREW DAVID · 2011 to 2017
$2.6M
NHGRI NIH HHS R01 HG006015
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal and differentiation. Msi1 and miR-137 have opposite expression patterns and functions, and

Indexed as

Cell DifferentiationGene Expression Regulation, NeoplasticNeurogenesisAnimalsCell ProliferationCell Transformation, NeoplasticGlioblastomaHumansMicroRNAsNerve Tissue ProteinsRNA-Binding ProteinsSignal TransductionTumor Cells, CulturedMicroRNAsMIRN137 microRNA, humanMSI1 protein, humanNerve Tissue ProteinsRNA-Binding ProteinsglioblastomamiR-137miRNAMusashi1neurogenesisRNA-binding protein

Identifiers

PMID31004009
PMCPMC6573790
OpenAlexW2923947832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.