Evidence map›Paper›PMID 31003856›Full record

ArticleJournal of psychosomatic research2019

Cannabis abuse and dependence in kidney transplant candidates.

Amy L Stark, LaTonya J Hickson, Beth R Larrabee, Nuria J Thusius, Victor M Karpyak, Daniel K Hall-Flavin, Terry D Schneekloth

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosomatic research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guideline
  2. Review
  3. The growing dilemma of legalized cannabis and heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Review
  4. Review
  5. The nephrologist's guide to cannabis and cannabinoids.Current opinion in nephrology and hypertension · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amy L StarkTexas Tech University Health Sciences Center, Department of Psychiatry, Amarillo, TX, USA; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
LaTonya J HicksonDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Beth R LarrabeeDepartment of Health Information Management, Mayo Clinic, Rochester, MN, USA.
Nuria J ThusiusDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.
Victor M KarpyakDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Daniel K Hall-FlavinDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Terry D SchneeklothDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. Electronic address: Schneekloth.Terry@mayo.edu.
Mayo Clinic · USTexas Tech University Health Sciences Center · USWinnMed · US

Funding

Mesenchymal stem cell senescence in diabetic nephropathy (K23 COVID Admin Supplement)K23DK109134 · NIDDK · MAYO CLINIC ROCHESTER · PI HICKSON, LATONYA J · 2016 to 2021
$1.0M
NIDDK NIH HHS K23 DK109134
6 · The paper itself

Abstract

objectiveCannabis is the most commonly used non-alcohol intoxicant in the general population. There are no consistent guidelines on the implications of cannabis abuse and dependence (CAD) in kidney transplant candidates. The aims of this study were to characterize kidney transplant candidates with comorbid CAD and examine the implications of CAD on transplant candidacy.

methodThis was a retrospective cohort study of kidney transplant candidates meeting diagnostic criteria for CAD at a tertiary center from 2012 to 2016. Candidates were reviewed for psychiatric and substance use disorders (SUDs), family history, and medical variables. The cohort was divided by severity of CAD and transplant listing status for comparisons. Statistical analysis included Kruskal-Wallis tests for continuous variables and Fisher's Exact Test for categorical variables.

resultsSixty-one of 2067 (3%) kidney transplant candidates met criteria for CAD, and 13/61 (21%) underwent transplantation. Of 61, 58% smoked cannabis daily, 47% had alcohol dependence history, 31% had other illicit drug dependencies, 38% were smokers, 60% had a SUD family history, and 42% and 27% had depressive and anxiety disorders, respectively. Severity of CAD was inversely associated with transplant listing; those with cannabis abuse were more often listed than those with dependence (67% vs 33%, p = .02) by study end. Three case presentations illustrate cannabis-related issues.

conclusionIn this cohort, kidney transplant candidates with comorbid CAD have high prevalence of other substance use disorders, psychiatric comorbidities, and strong family histories of addictions that resemble other SUD populations. These findings have implications for pre-transplant screening and treatment and post-transplant monitoring.

Indexed as

AdultAlcoholismAnxietyCohort StudiesComorbidityDepressionFemaleHumansKidney TransplantationMaleMarijuana AbuseMiddle AgedPrevalenceRetrospective StudiesCannabisKidney transplantationMarijuanaSubstance abuse

Identifiers

PMID31003856
PMCPMC6545133
OpenAlexW2939297972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.