PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery.

Meishan Chen, Xiangru Feng, Weiguo Xu, Yanqiao Wang, Yanan Yang, Zhongyu Jiang, Jianxun Ding

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Fibroblast activation protein targeting radiopharmaceuticals: From drug design to clinical translation.Acta pharmaceutica Sinica. B · 2025
Review
Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics.Nanomaterials (Basel, Switzerland) · 2023
Review
Special Issue: "Smart and Functional Polymers".Molecules (Basel, Switzerland) · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meishan ChenChemical Engineering Institute, Changchun University of Technology, 2055 Yan'an Street, Changchun 130012, China. mschen@ciac.ac.cn.

Xiangru FengKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. xrfeng@ciac.ac.cn.

Weiguo XuKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. wgxu@caic.ac.cn.

Yanqiao WangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. candyqiao77@jlu.edu.cn.

Yanan YangChemical Engineering Institute, Changchun University of Technology, 2055 Yan'an Street, Changchun 130012, China. yangyanan@ccut.edu.cn.

Zhongyu JiangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. zyjiang@ciac.ac.cn.

Jianxun DingKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. jxding@ciac.ac.cn.

Funding

National Key Research and Development Program of China 2016YFC1100701National Natural Science Foundation of China 51873207, 51803006, 51833010, 51673190, 51603204, 51673187, and 51520105004Science and Technology Development Program of Jilin Province 20190201068JC

6 · The paper itself

Abstract

In recent years, polyureas with dynamic hindered urea bonds (HUBs), a class of promising biomedical polymers, have attracted wide attention as a result of their controlled hydrolytic properties. The effect of the chemical structures on the properties of polyureas and their assemblies has rarely been reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyureas from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. The amphiphilic polyurea composed of hydrophobic cyclohexyl-tert-butyl polyurea and hydrophilic poly(ethylene glycol) (PEG) was synthesized for the controlled delivery of the antitumor drug paclitaxel (PTX). The PTX-loaded PEGylated polyurea micelle more effectively entered into the murine breast cancer 4T1 cells and inhibited the corresponding tumor growth in vitro and in vivo. Therefore, the PEGylated polyurea with adjustable degradation might be a promising polymer matrix for drug delivery.

Indexed as

Drug Delivery SystemsAnimalsCell DeathCell Line, TumorCell ProliferationFemaleMice, Inbred BALB CMicellesPaclitaxelPolyethylene GlycolsPolymersProton Magnetic Resonance SpectroscopyUreaMicellesPaclitaxelPolyethylene GlycolsPolymerspolyureaUreaamphiphilic copolymercancer chemotherapycontrolled drug deliveryhydrolyzable polyureamicelle

Identifiers

PMID31003544

DOI10.3390/molecules24081538

PMCPMC6515048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.