ArticleGels (Basel, Switzerland)2019
Investigating Manuka Honey Antibacterial Properties When Incorporated into Cryogel, Hydrogel, and Electrospun Tissue Engineering Scaffolds.
Article in Gels (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Subchondral Bone Regeneration of the Porcine Knee Joint Using α-TCP Biocement Enriched with Manuka Honey-Qualitative Pilot Study.Life (Basel, Switzerland) · 2026Article
- A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications.Gels (Basel, Switzerland) · 2025Review
- Honey as a Natural Antimicrobial.Antibiotics (Basel, Switzerland) · 2025Review
- Manuka honey as a non-antibiotic alternative againstFrontiers in cellular and infection microbiology · 2024Review
- Antibacterial Efficacy of Manuka Honey-Doped Chitosan-Gelatin Cryogel and Hydrogel Scaffolds in Reducing Infection.Gels (Basel, Switzerland) · 2023Article
- Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings.Gels (Basel, Switzerland) · 2023Article
- Evaluation of bacterial attachment on mineralized collagen scaffolds and addition of manuka honey to increase mesenchymal stem cell osteogenesis.Biomaterials · 2023Article
- PDDA/Honey Antibacterial Nanofiber Composites for Diabetic Wound-Healing: Preparation, Characterization, and In Vivo Studies.Gels (Basel, Switzerland) · 2023Article
- Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration.Polymers · 2023Article
- Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications.Materials today. Bio · 2022Review
- Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications.Pharmaceutics · 2022Review
- Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures.Gels (Basel, Switzerland) · 2022Article
- A Review on Recent Progress of Stingless Bee Honey and Its Hydrogel-Based Compound for Wound Care Management.Molecules (Basel, Switzerland) · 2022Review
- Valuable effect of Manuka Honey in increasing the printability and chondrogenic potential of a naturally derived bioink.Materials today. Bio · 2022Article
- Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance.Gels (Basel, Switzerland) · 2022Review
- "Green" Biomaterials: The Promising Role of Honey.Journal of functional biomaterials · 2021Review
- The Potential of Honeybee Products for Biomaterial Applications.Biomimetics (Basel, Switzerland) · 2021Review
- Antibacterial agent-releasing scaffolds in dental tissue engineering.Journal of advanced periodontology & implant dentistry · 2021Review
- Therapeutic Potential of Bioactive Compounds in Honey for Treating Osteoarthritis.Frontiers in pharmacology · 2021Review
- Manuka honey microneedles for enhanced wound healing and the prevention and/or treatment of Methicillin-resistant Staphylococcus aureus (MRSA) surgical site infection.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honey is well-known for its wound healing capability and Manuka honey (MH) contains a unique Manuka factor, providing an additional antibacterial agent. Previously, there has not been a practical way to apply MH to a wound site, which renders treatment for an extended period extremely difficult. Tissue-engineered scaffolds offer an alternative treatment method to standard dressings by providing varying geometries to best treat the specific tissue. MH was incorporated into cryogels, hydrogels, and electrospun scaffolds to assess the effect of scaffold geometry on bacterial clearance and adhesion, as well as cellular adhesion. Electrospun scaffolds exhibited a faster release due to the nanoporous fibrous geometry which led to a larger partial bacterial clearance as compared to the more three-dimensional cryogels (CG) and hydrogels (HG). Similarly, the fast release of MH from the electrospun scaffolds resulted in reduced bacterial adhesion. Overall, the fast MH release of the electrospun scaffolds versus the extended release of the HG and CG scaffolds provides differences in cellular/bacterial adhesion and advantages for both short and long-term applications, respectively. This manuscript provides a comparison of the scaffold pore structures as well as bacterial and cellular properties, providing information regarding the relationship between varying scaffold geometry and MH efficacy.
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Registered trials
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