Evidence map›Paper›PMID 31003494›Full record

ArticleMolecules (Basel, Switzerland)2019

Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution.

Anton Larenkov, Victor Bubenschikov, Artur Makichyan, Maria Zhukova, Alina Krasnoperova, Galina Kodina

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Pharmaceutics · 2025
    Article
  2. Article
  3. Good practices forEJNMMI radiopharmacy and chemistry · 2024
    Review
  4. Article
  5. Review
  6. Metal-Based Radiopharmaceuticals in Inorganic Chemistry.Molecules (Basel, Switzerland) · 2023
    Article
  7. Evaluation of differentScientific reports · 2022
    Article
  8. A new solid target design for the production ofAmerican journal of nuclear medicine and molecular imaging · 2022
    Article
  9. Separation ofMolecules (Basel, Switzerland) · 2021
    Article
  10. A kit formulation for the preparation of [Nuclear medicine and biology
    Article
  11. [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anton LarenkovState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia. anton.larenkov@gmail.com.
Victor BubenschikovState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia. bubenschikov2011@yandex.ru.
Artur MakichyanState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia. makbezh@gmail.com.
Maria ZhukovaState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia. 9053522@mail.ru.
Alina KrasnoperovaState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia. kalina188@mail.ru.
Galina KodinaState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia. gkodina@yandex.ru.

Funding

Ministry of Education and Science of the Russian Federation State Contract № 14.N08.11.0162
6 · The paper itself

Abstract

Zirconium-89 is a promising radionuclide for nuclear medicine. The aim of the present work was to find a suitable method for obtaining zirconium-89 solutions for radiopharmaceutical purposes. For this purpose, the ion exchange behavior of zirconium-89 solutions was studied. Radio-TLC (thin layer chromatography) and biodistribution studies were carried out to understand speciation of zirconium-89 complexes and their role in the development of new radiopharmaceuticals. Three methods of zirconium-89 isolation were studied using ZR (hydroxamate) and Chelex-100 resins. It was found that ZR-resin alone is not enough to obtain stable zirconium-89 formulations. An easy and effective method of reconstitution of [

Indexed as

RadiochemistryAnionsChloridesDrug CompoundingIon ExchangeOxalatesRadioisotopesRadiopharmaceuticalsResins, SyntheticSolutionsTissue DistributionZirconiumAnionsChelex 100ChloridesOxalatesRadioisotopesRadiopharmaceuticalsResins, SyntheticSolutionsZirconiumZirconium-89Chelex-100citrateDFOoxalatepurificationradiochemical puritystabilitytranschelationzirconium-89ZR hydroxamate resin

Identifiers

PMID31003494
PMCPMC6514948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.