ArticleJournal of clinical medicine2019
Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sarcopenia, frailty syndrome and obstructive sleep apnea as elements of the aging phenotype in head and neck cancer and upper airway disorders: a scoping review.Frontiers in medicine · 2026Pooled it
- The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans.European geriatric medicine · 2021Trial
- Nutritional Status Predicts Functional Recovery and Adverse Outcomes in Older Adults: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association between sarcopenia and frailty in middle-aged and elder population: Findings from the China health and retirement longitudinal study.Journal of global health · 2024Article
- Acetate derived from the intestinal tract has a critical role in maintaining skeletal muscle mass and strength in mice.Physiological reports · 2024Article
- Correspondence: Methodological considerations in evaluating sarcopenia and frailty in elderly gastrointestinal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Article
- Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome.Immunity & ageing : I & A · 2023Article
- Exploring the variability of sarcopenia prevalence in a research population using different disease definitions.Aging clinical and experimental research · 2023Article
- Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients.Journal of cachexia, sarcopenia and muscle · 2023Article
- Prevalence and Clinical Conditions Related to Sarcopaenia among Older Persons Living in the Community.Journal of clinical medicine · 2022Article
- Physical activity in older adults with metastatic gastrointestinal cancer: a pilot and feasibility study.BMJ open sport & exercise medicine · 2022Article
- Lymphocytes as a Biomarker of Frailty Syndrome: A Scoping Review.Diseases (Basel, Switzerland) · 2021Article
- Relationships Between Age, Frailty, Length of Care Home Residence and Biomarkers of Immunity and Inflammation in Older Care Home Residents in the United Kingdom.Frontiers in aging · 2021Article
- Article
- Body Composition and Exercise Performance in Youth With a Fontan Circulation: A Bio-Impedance Based Study.Journal of the American Heart Association · 2020Observational
- Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity.Journal of clinical medicine · 2020Article
- Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence, relationships and outcomes of sarcopenia and frailty in polypathological patients remain unknown. We performed a multicenter prospective observational study in six hospitals in order to assess prevalence, clinical features, outcome and associated risk factors of sarcopenia and frailty in a hospital-based population of polypathological patients. The cohort was recruited by performing prevalence surveys every 14 days during the inclusion period (March 2012-June 2016). Sarcopenia was assessed by means of EWGSOP criteria and frailty by means of Fried's criteria. Skeletal muscle mass was measured by tetrapolar bioimpedanciometry. All patients were followed for 12 months. Factors associated with sarcopenia, frailty and mortality were analyzed by multivariate logistic regression, and Kaplan-Meier curves. A total of 444 patients (77.3 ± 8.4 years, 55% males) were included. Sarcopenia was present in 97 patients (21.8%), this being moderate in 54 (12.2%), and severe in 43 (9.6%); frailty was present in 278 patients (62.6%), and 140 (31.6%) were pre-frail; combined sarcopenia and frailty were present in the same patient in 80 (18%) patients. Factors independently associated to the presence of both, sarcopenia and frailty were female gender, older age, different chronic conditions, poor functional status, low body mass index, asthenia and depressive disorders, and low leucocytes and lymphocytes count. Mortality in the 12-months follow-up period was 40%. Patients with sarcopenia, frailty or both survived significantly less than those without these conditions. Sarcopenia and frailty are frequent and interrelated conditions in polypathological patients, shadowing their survival. Their early recognition and management could improve health-related outcomes in this population.
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