Evidence map›Paper›PMID 31003171›Full record

ArticleThe International journal on drug policy2019

Evaluation of contingency management as a strategy to improve HCV linkage to care and treatment in persons attending needle and syringe programs: A pilot study.

B L Norton, M A Bachhuber, R Singh, L Agyemang, J H Arnsten, C O Cunningham, A H Litwin

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

B L NortonDivision of General Internal Medicine, Montefiore Medical Center, United States. Electronic address: bnorton@montefiore.org.
M A BachhuberDivision of General Internal Medicine, Montefiore Medical Center, United States.
R SinghNew York University, United States.
L AgyemangDivision of General Internal Medicine, Montefiore Medical Center, United States.
J H ArnstenDivision of General Internal Medicine, Montefiore Medical Center, United States.
C O CunninghamDivision of General Internal Medicine, Montefiore Medical Center, United States.
A H LitwinDivision of General Internal Medicine, Montefiore Medical Center, United States. Electronic address: alitwin@ghs.org.
Montefiore Medical Center · USNew York University · US

Funding

Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HARRIS GOLDSTEIN · 2017 to 2026
$28.3M
Intensive Models of HCV Care for Injection Drug UsersR01DA034086 · NIDA · CLEMSON UNIVERSITY · PI LITWIN, ALAIN HARRIS · 2012 to 2016
$3.7M
HIV and Substance Abuse Clinical Addiction Research and Education (CARE) ProgramR25DA023021 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ARNSTEN, JULIA H. · 2007 to 2014
$2.7M
Adaptation and testing of a primary care HCV group medical treatment interventionK23DA039060 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NORTON, BRIANNA · 2015 to 2019
$948k
Mentoring researchers on drug abuse and HIVK24DA036955 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUNNINGHAM, CHINAZO · 2014 to 2019
$911k
Leveraging the electronic health record to reduce opioid analgesic prescriptionsK08DA043050 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BACHHUBER, MARCUS A · 2017 to 2018
$223k
NIAID NIH HHS P30 AI124414NIDA NIH HHS K08 DA043050NIDA NIH HHS K23 DA039060NIDA NIH HHS K24 DA036955NIDA NIH HHS R01 DA034086NIDA NIH HHS R25 DA023021
6 · The paper itself

Abstract

backgroundA greater proportion of HCV-infected people who inject drugs (PWID) need to be linked to care for HCV antiviral treatment. This study sets out to evaluate the efficacy of contingency management (CM) for improving HCV linkage to care, treatment initiation, adherence, and cure for PWID recruited from a needle and syringe program.

methodsBetween March 2015 and April 2016, 20 participants were enrolled into the CM arm, and then subsequently enrolled 20 participants in the enhanced standard of care (eSOC) arm. Participants in the eSOC arm received an expedited appointment and a round-trip transit card. Participants enrolled in the CM arm received eSOC plus $25 for up to ten HCV clinical visits and $10 for each returned weekly medication blister pack. Adherence was measured via electronic blister packs.

resultsOverall the median age was 47 years; most were men (67%) and Hispanic (69%). There were no significant differences in demographic characteristics between participants in the study arms. In the CM arm 74% were linked to HCV care, compared to 30% in the eSOC arm (p = 0.01). In the CM arm, 75% (9/12) of treatment eligible participants initiated treatment, compared to 100%(4/4) in the eSOC arm (p = 0.53). All patients (9/9) achieved cure in the CM arm, as compared to 75% (3/4) of patients in the eSOC arm. There were no differences in adherence between study arms.

conclusionsIn this pilot study, contingency management led to higher rates of HCV linkage to care for PWID, as compared to standard of care. CM should be considered as a possible intervention to improve the HCV treatment cascade for PWID.

Indexed as

AdultAntiviral AgentsDrug UsersFemaleHepatitis CHumansMaleMiddle AgedNeedle-Exchange ProgramsNeedlesPilot ProjectsSubstance Abuse, IntravenousSyringesAntiviral AgentsContingency managementHCVLinkage to carePersons who inject drugs (PWID)Syringe exchange programs

Identifiers

PMID31003171
PMCPMC6704472
OpenAlexW2936328581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.