Evidence map›Paper›PMID 31003136›Full record

ArticlePsychoneuroendocrinology2019

Examining reactivity patterns in burnout and other indicators of chronic stress.

Magdalena K Wekenborg, Bernadette von Dawans, LaBarron K Hill, Julian F Thayer, Marlene Penz, Clemens Kirschbaum

Abstract read
In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. The Relationship between Flow Experience and Burnout Symptoms: A Systematic Review.International journal of environmental research and public health · 2022
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  8. Association Between Phasic Vagal-Mediated Heart Rate Variability and Momentary Exhaustion in Daily Life.Stress and health : journal of the International Society for the Investigation of Stress · 2025
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  14. Validation of an ELISA kit to measure allopregnanolone in human and equine hair.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magdalena K WekenborgDepartment of Psychology, TU Dresden, Germany. Electronic address: magdalena.wekenborg@tu-dresden.de.
Bernadette von DawansDepartment of Biological and Clinical Psychology, University of Trier, Trier, Germany.
LaBarron K HillDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Julian F ThayerDepartment of Psychology, The Ohio State University, Columbus, USA.
Marlene PenzDepartment of Psychology, TU Dresden, Germany.
Clemens KirschbaumDepartment of Psychology, TU Dresden, Germany.

Funding

Depression and Heart Failure Disease ProgressionR01HL121708 · NHLBI · DUKE UNIVERSITY · PI SHERWOOD, ANDREW · 2014 to 2018
$4.2M
NHLBI NIH HHS R01 HL121708NIMHD NIH HHS L60 MD009947
6 · The paper itself

Abstract

introductionBurnout symptomatology is associated with various negative health consequences; however, the mechanisms underlying these associations remain unclear. One potential pathway involves alterations in the acute stress response. The aims of the present study were to examine burnout-associated alterations in stress-reactivity patterns, during a standardized social stressor compared to a control condition, as well as to examine whether effects associated with greater burnout symptomatology were distinct from other, conceptually overlapping indicators of chronic stress (i.e. depressive symptomatology and elevated hair cortisol concentration [HCC]). MATERIALS AND

methodsIn a randomized two-factor design a total of 70 employed males with varying burnout symptoms but without evidence of physical or psychiatric disease were exposed to the Trier Social Stress Test for Groups (TSST-G) or a non-stressful control condition. Acute stress reactivity was assessed using self-report stress measures and non-invasive biomarkers. Associations among acute stress reactivity, burnout and depressive symptoms (assessed with self-report measures), as well as HCC were analysed using repeated measure ANCOVAs and moderation analysis.

resultsBurnout symptomatology was associated with elevated stress perception independent of the experimental condition. In addition, depressive symptomatology was associated with enhanced anticipatory appraisal, whereas HCC was not related to any subjective stress measure. On a physiological level, burnout and depressive symptomatology, as well as HCC were associated with a pattern of blunted cardiovascular reactivity, however the timing of this effect varied.

conclusionOur results indicate burnout-associated modulations in stress reactivity, which diverge, at least partly, from other indicators of chronic stress.

Indexed as

AdultAgedBurnout, ProfessionalDepressionHairHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemSelf ReportStress, PsychologicalHydrocortisoneBurnoutChronic stressDepressionHair cortisolStress reactivityTSST

Identifiers

PMID31003136
PMCPMC6864749

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.