Evidence map›Paper›PMID 31003122›Full record

ArticleVirology2019

Virus survival and fitness when multiple genotypes and subtypes of influenza A viruses exist and circulate in swine.

Jingjiao Ma, Huigang Shen, Chester McDowell, Qinfang Liu, Michael Duff, Jinhwa Lee, Yuekun Lang, Dick Hesse, Juergen A Richt, Wenjun Ma

Open access · greenAbstract read
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jingjiao MaDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Huigang ShenDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Chester McDowellDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Qinfang LiuDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Michael DuffDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Jinhwa LeeDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Yuekun LangDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Dick HesseDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Juergen A RichtDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Wenjun MaDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA. Electronic address: wjma@ksu.edu.
Kansas State University · US

Funding

Evolution and biology of Influenza B viruses in pigsR21AI121906 · NIAID · KANSAS STATE UNIVERSITY · PI MA, WENJUN · 2017 to 2018
$412k
NIAID NIH HHS HHSN272201400006CNIAID NIH HHS R21 AI121906
6 · The paper itself

Abstract

We performed swine influenza virus (SIV) surveillance in Midwest USA and isolated 100 SIVs including endemic and reassortant H1 and H3 viruses with 2009 pandemic H1N1 genes. To determine virus evolution when different genotypes and subtypes of influenza A viruses circulating in the same swine herd, a virus survival experiment was conducted in pigs mimicking field situations. Five different SIVs were used to infect five pigs individually, then two groups of sentinel pigs were introduced to investigate virus transmission. Results showed that each virus replicated efficiently in lungs of each infected pig, but only reassortant H3N2 and H1N2v viruses transmitted to the primary contact pigs. Interestingly, the parental H1N2v was the majority of virus detected in the second group of sentinel pigs. These data indicate that the H1N2v seems to be more viable in swine herds than other SIV genotypes, and reassortment can enhance viral fitness and transmission.

Indexed as

AnimalsEpidemiological MonitoringGenetic FitnessGenotypeInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H1N2 SubtypeInfluenza A Virus, H3N2 SubtypeMidwestern United StatesOrthomyxoviridae InfectionsPhylogenyReassortant VirusesSwineSwine DiseasesVirus ReplicationH1N2vPigsSurveillanceSwine influenza virusVirus competition and survival

Identifiers

PMID31003122
PMCPMC7587047
OpenAlexW2936537727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.