Evidence map›Paper›PMID 31003069›Full record

ArticleNeuroImage. Clinical2019

Dopamine receptor D

P M Butler, W Chiong, D C Perry, Z A Miller, E D Gennatas, J A Brown, L Pasquini, A Karydas, D Dokuru, G Coppola and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

P M ButlerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: Monroe.Butler@ucsf.edu.
W ChiongDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
D C PerryDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Z A MillerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
E D GennatasDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
J A BrownDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
L PasquiniDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
A KarydasDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
D DokuruDepartments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
G CoppolaDepartments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
V E SturmDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
A L BoxerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
M L Gorno-TempiniDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
H J RosenDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
J H KramerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
B L MillerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
W W SeeleyDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity Memory and Aging Center · USUniversity of California, Los Angeles · US

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2009 to 2018
$7.4M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Neurobiological Basis of Emotion Regulation Trajectories in Early Alzheimer's DiseaseR01AG057204 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STURM, VIRGINIA EMILY · 2017 to 2021
$3.9M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal DementiaR01AG026938 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2005 to 2009
$2.5M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS K23 AG045289NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG026938NIA NIH HHS R01 AG052496NIA NIH HHS R01 AG057204NIA NIH HHS RC1 AG035610NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG052943NIA NIH HHS U24 AG021886NIDCD NIH HHS K24 DC015544NIMH NIH HHS R01 MH097268NINDS NIH HHS P30 NS062691NINDS NIH HHS R01 NS050915NINDS NIH HHS R01 NS100440NINDS NIH HHS R56 NS050915
6 · The paper itself

Abstract

objectiveWe aimed to understand the impact of dopamine receptor D

methods337 subjects, including healthy controls, patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) underwent genotyping, structural MRI, and cognitive/behavioral testing. We conducted whole-brain voxel-based morphometry to examine the relationship between DRD

resultsDRD

conclusionsWe conclude that DRD

Indexed as

AgedAlzheimer DiseaseAtrophyBrainFemaleFrontotemporal DementiaHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPolymorphism, GeneticReceptors, Dopamine D4SyndromeReceptors, Dopamine D4Anterior cingulate cortexApathyDRD(4)Frontotemporal dementiaInsulaSalience network

Identifiers

PMID31003069
PMCPMC6475809
OpenAlexW2936554390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.