ReviewMechanisms of ageing and development2019
Frailty biomarkers in humans and rodents: Current approaches and future advances.
Review in Mechanisms of ageing and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 105 citations in OpenAlex.
- Supervised Exercise Intervention Restores Physical Activity and MultiOMIC-Derived Frailty Biomarkers in Older Adults.Journal of cachexia, sarcopenia and muscle · 2026Article
- High frailty index scores predict mortality and changes in blood-based biomarkers in aging female mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Developing and internally validating AI-based aging resilience biomarkers in non-human primates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Exploring heart rate variability as a biomarker for frailty: A narrative review.European journal of clinical investigation · 2026Review
- Longitudinal Associations Between Biomarkers and Frailty in Older Adults: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- Revisiting the social frailty index in aging adults: relevance and implications for an emerging construct.GeroScience · 2026Article
- Social and clinical frailty indices in aging mice: a comparative analysis of longitudinal and cross-sectional designs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The functional roles and mechanisms of polyamines in age-related bone diseases.Cellular and molecular life sciences : CMLS · 2025Review
- DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice.bioRxiv : the preprint server for biology · 2025Article
- The Impact of Flavonoids and Omega-3 in Mitigating Frailty Syndrome to Improve Treatment Outcomes in Peripheral Artery Disease (PAD) Patients.Nutrients · 2025Review
- Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach.GeroScience · 2025Article
- Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.npj aging · 2025Article
- Long-term smoking contributes to aging frailty and inflammatory response.Biomolecules & biomedicine · 2025Article
- The connection between depression and frailty among older adults with obstructive sleep apnea: results from a multicenter cohort study.Sleep & breathing = Schlaf & Atmung · 2025Article
- The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice.GeroScience · 2025Article
- Digital home-based multimodal prehabilitation of colorectal cancer patients prior to surgery (the dHOPE study): a non-inferiority clinical trial protocol.Frontiers in digital health · 2025Article
- Animal Models Relevant for Geroscience: Current Trends and Future Perspectives in Biomarkers, and Measures of Biological Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging.GeroScience · 2024Article
- The intersection of frailty and metabolism.Cell metabolism · 2024Review
- Identification of novel FRedox biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.