ArticlePloS one2019
Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between interleukin-2 cytokine levels and Plasmodium infections: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Extended analysis on peripheral blood cytokines correlated with hepatitis B virus viral load in chronically infected patients - a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Interleukin-5 levels in relation to malaria severity: a systematic review.Malaria journal · 2023Pooled it
- Hepatitis B Virus andViruses · 2025Article
- Impact of hepatitis B virus infection in patients with plasmodium parasites in selected health facilities in Accra, Ghana.BMC infectious diseases · 2025Article
- Socioeconomic determinants of malaria and hepatitis infections: insights from the Federal Medical Center, Makurdi, North Central, Nigeria.BMC public health · 2024Article
- Hepatitis B Virus Infection: A Mini Review.Viruses · 2024Review
- Alcohol intake, smoking, self-medication practices and burden of anaemia among traders in Tamale metropolis of Ghana.BMC research notes · 2023Article
- Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases.Journal of clinical medicine · 2023Article
- Serum Metabolome Signatures Characterizing Co-Infection ofDiseases (Basel, Switzerland) · 2023Article
- Hepatitis B and Asymptomatic Malaria Infection among Pregnant Women in a Semiurban Community of North-Central Nigeria.Journal of environmental and public health · 2021Article
- Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities.BMC infectious diseases · 2020Article
- Evaluation of hepatic and kidney dysfunction among newly diagnosed HIV patients with viral hepatitis infection in Cape Coast, Ghana.BMC research notes · 2019Article
- Acute Kidney Injury and Jaundice in a Patient With Concurrent Severe Malaria and Acute Exacerbation of Hepatitis B.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.
methodsClinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group).
resultsWomen with Malaria+CHB maintained appreciably normal hemoglobin levels (mean±SEM = 10.3±0.3 g/dL). That notwithstanding, Liver function test showed significantly elevated levels of alanine aminotransferase, aspartate aminotransferase and total bilirubin [P<0.001 for all comparisons]. Similarly, the Malaria+CHB group had significantly elevated pro-inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 [P<0.05 for all comparisons]. In women with Malaria+CHB, correlation analysis showed significant negative association of the pro-inflammatory cytokines responses with malaria parasitemia [IL-1β (P<0.001; r = -0.645), IL-6 (P = 0.046; r = -0.394) and IL-12 (P = 0.011; r = -0.49)]. On the other hand, the pro-inflammatory cytokine levels positively correlated with HBV viremia [TNF-α (P = 0.004; r = 0.549), IL-1β (P<0.001; r = 0.920), IL-6 (P<0.001; r = 0.777), IFN-γ (P = 0.002; r = 0.579), IL-2 (P = 0.008; r = 0.512) and IL-12 (P<0.001; r = 0.655)]. Also, for women in the Malaria+CHB group, parasitemia was observed to diminish HBV viremia [P = 0.003, r = -0.489].
conclusionPut together the findings suggests that Malaria+CHB could exacerbate inflammatory cytokine responses and increase susceptibility to liver injury among pregnant women in endemic settings.
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