ArticlePLoS biology2019
Task-related hemodynamic responses are modulated by reward and task engagement.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Heterogeneous Effects of Cognitive Arousal on the Contrast Response in Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Adaptive decision-making depends on pupil-linked arousal in rats performing tactile discrimination tasks.Journal of neurophysiology · 2023Article
- Representations in human primary visual cortex drift over time.Nature communications · 2023Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
- Article
- Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cognition is entangled with metabolism: relevance for resting-state EEG-fMRI.Frontiers in human neuroscience · 2023Article
- Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022Review
- Article
- Article
- Behavioral and physiological monitoring for awake neurovascular coupling experiments: a how-to guide.Neurophotonics · 2022Article
- How the value of the environment controls persistence in visual search.PLoS computational biology · 2021Article
- Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.PLoS biology · 2021Article
- Iliski, a software for robust calculation of transfer functions.PLoS computational biology · 2021Article
- Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Adaptive modulation of brain hemodynamics across stereotyped running episodes.Nature communications · 2020Article
- Task-related activity in human visual cortex.PLoS biology · 2020Article
- Article
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4 authors.
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Abstract
Hemodynamic recordings from visual cortex contain powerful endogenous task-related responses that may reflect task-related arousal, or "task engagement" distinct from attention. We tested this hypothesis with hemodynamic measurements (intrinsic-signal optical imaging) from monkey primary visual cortex (V1) while the animals' engagement in a periodic fixation task over several hours was varied through reward size and as animals took breaks. With higher rewards, animals appeared more task-engaged; task-related responses were more temporally precise at the task period (approximately 10-20 seconds) and modestly stronger. The 2-5 minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these reversed with ramp-like increases during low reward. The blood volume increased even more sharply when the animal shut his eyes and disengaged completely from the task (5-10 minutes). We propose a mechanism that controls vascular tone, likely along with local neural responses in a manner that reflects task engagement over the full range of timescales tested.
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