Evidence map›Paper›PMID 31002535›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Myonectin deletion promotes adipose fat storage and reduces liver steatosis.

Hannah C Little, Susana Rodriguez, Xia Lei, Stefanie Y Tan, Ashley N Stewart, Ageline Sahagun, Dylan C Sarver, G William Wong

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Myokines and mitochondrial function in cardiometabolic diseases.Journal of physiology and biochemistry · 2026
    Review
  5. CTRP10 is required for optimal motor function.The Journal of biological chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah C LittleDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Susana RodriguezDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xia LeiDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stefanie Y TanDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ashley N StewartDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ageline SahagunDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dylan C SarverDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G William WongDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
CTRP and Metabolic ControlR01DK084171 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Guang William Wong · 2010 to 2026
$8.0M
Elucidation of the role of myonectin in regulating lipid partitioning and metabolismF31DK116537 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LITTLE, HANNAH · 2017 to 2018
$84k
NIDDK NIH HHS F31 DK116537NIDDK NIH HHS R01 DK084171NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

We recently described myonectin (also known as erythroferrone) as a novel skeletal muscle-derived myokine with metabolic functions. Here, we use a genetic mouse model to determine myonectin's requirement for metabolic homeostasis. Female myonectin-deficient mice had larger gonadal fat pads and developed mild insulin resistance when fed a high-fat diet (HFD) and had reduced food intake during refeeding after an unfed period but were otherwise indistinguishable from wild-type littermates. Male mice lacking myonectin, however, had reduced physical activity when fed

Indexed as

AdipocytesAdipose TissueAdiposityAnimalsCytokinesDiet, High-FatFatty LiverFemaleHomeostasisInsulinInsulin ResistanceLipid MetabolismLipoproteins, VLDLLiverMaleMiceCytokinesErfe protein, mouseInsulinLipoproteins, VLDLMuscle ProteinsTriglyceridesvery low density lipoprotein triglyceridecarbohydrate metabolismdiabeteslipid metabolismmyokineobesity

Identifiers

PMID31002535
PMCPMC6593887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.