Evidence map›Paper›PMID 31002480›Full record

ArticleAutism research : official journal of the International Society for Autism Research2020

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse.

Anita J L Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin

Open access · hybridAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
  2. Review
  3. Article
  4. A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome.Autism research : official journal of the International Society for Autism Research · 2025
    Review
  5. Review
  6. Review
  7. Frontiers in neuroscience · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anita J L LeembruggenDepartment of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Gayathri K BalasuriyaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.ORCID 0000-0003-3411-4543
Jinghong ZhangDepartment of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Shana SchokmanSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Kristy SwiderskiCentre for Muscle Research, Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Joel C BornsteinDepartment of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Jess NithianantharajahFlorey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
Elisa L Hill-YardinDepartment of Physiology, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-4146-7198
The University of Melbourne · AURMIT University · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cause is unknown. Mutations in genes encoding synaptic proteins including Neuroligin-3 are associated with autism. Mice lacking Neuroligin-3 (Nlgn3

Indexed as

AnimalsCell Adhesion Molecules, NeuronalColonDisease Models, AnimalGastrointestinal DiseasesGastrointestinal MotilityMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsCell Adhesion Molecules, NeuronalMembrane ProteinsNerve Tissue Proteinsneuroligin 3autismgastrointestinal symptomsgut motilityimmunofluorescencemouse modelsNeuroligin-3

Identifiers

PMID31002480
PMCPMC7317711
OpenAlexW2938665189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.