Evidence map›Paper›PMID 31002191›Full record

ArticlePsychophysiology2019

Autonomic correlates of lifetime suicidal thoughts and behaviors among adolescents with a history of depression.

Xiao Yang, Shimrit Daches, Charles J George, Enikő Kiss, Krisztina Kapornai, Ildikó Baji, Maria Kovacs

Abstract read
In one paragraph

Article in Psychophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao YangDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Shimrit DachesDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Charles J GeorgeDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Enikő KissDepartment of Child and Adolescent Psychiatry, University of Szeged, Szeged, Hungary.
Krisztina KapornaiDepartment of Child and Adolescent Psychiatry, University of Szeged, Szeged, Hungary.
Ildikó BajiDepartment of Child and Adolescent Psychiatry, University of Szeged, Szeged, Hungary.
Maria KovacsDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Funding

SEARCH FOR GENETIC FACTORS IN CHILDHOOD ONSET DEPRESSIONP01MH056193 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KENNEDY, JAMES · 1997 to 2006
$20.3M
Biobehavioral Inflexibility and Risk for Juvenile-Onset DepressionR01MH084938 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOVACS, MARIA · 2009 to 2024
$7.4M
NIMH NIH HHS P01 MH056193NIMH NIH HHS PO1 MH056193NIMH NIH HHS R01 MH084938NIMH NIH HHS RO1 MH084938
6 · The paper itself

Abstract

Suicidal thoughts and behaviors (STBs) have been associated with emotion dysregulation and atypical responses to affective and stressful stimuli. To investigate the psychophysiology involved, we measured changes in respiratory sinus arrhythmia (RSA) and cardiac pre-ejection period (PEP; indexing parasympathetic and sympathetic functioning, respectively) in response to stressful- and sadness-eliciting laboratory probes. Our sample included adolescents with a history of depression and STBs (n = 177), adolescents with a history of depression but no history of STBs (n = 47), and healthy controls (n = 175). The outcome of interest was the most severe form of clinician-rated STBs across the subject's lifetime. In partial support of our hypotheses, during the stressful task, adolescents with a history of depression and STBs did not evidence the RSA decrease that was exhibited by controls and displayed greater PEP shortening compared to ever-depressed adolescents with no lifetime STBs. No group differences were found in either RSA or PEP reactivity to the sadness-eliciting stimulus. As expected, severity of STBs was positively correlated with the extent of PEP shortening during the stressful task. The results suggest that adolescents with a history of depression and STBs experience blunted parasympathetic responses to stress along with compensatory efforts. Our findings contribute to a better understanding of STBs among youths and underscore that future studies should examine physiological risk factors for these psychopathological outcomes.

Indexed as

Autonomic Nervous SystemSuicidal IdeationAdolescentAdultChildDepressive DisorderFemaleHumansMaleRespiratory Sinus ArrhythmiaStress, PsychologicalYoung Adultadolescentsautonomic nervous systemdepressionpre-ejection periodrespiratory sinus arrhythmiasuicidal thoughts and behaviors

Identifiers

PMID31002191
PMCPMC6650353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.