Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical "Hot-Wiring": An Under-explored Avenue for Therapeutic Development.

Ingrid K Wilt, Taylor P A Hari, William M Wuest

Open access · bronzeAbstract read

In one paragraph

Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 97% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Ingrid K WiltDepartment of Chemistry , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States.

Taylor P A HariDepartment of Chemistry , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States.

William M WuestDepartment of Chemistry , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States.ORCID 0000-0002-5198-7744

Emory University · US

Funding

Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026

$4.8M

NIGMS NIH HHS R35 GM119426

6 · The paper itself

Abstract

Biofilm-associated infections are linked to chronic and recurring illnesses. These infections are often not susceptible to current antibiotic treatments because of the protective exocellular matrix and subpopulations of dormant or "persister" cells. Targeting bacterial circuitry involved in biofilm formation, including two-component systems, quorum sensing, polysaccharide structural integrity, and cyclic nucleotide signaling pathways, has the potential to expand the existing arsenal of therapeutics, thus catalyzing a second golden age of antibiotic development.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial InfectionsBacterial Physiological PhenomenaBiofilmsDrug DevelopmentHumansNucleotides, CyclicPolysaccharides, BacterialQuorum SensingSignal TransductionAnti-Bacterial AgentsNucleotides, CyclicPolysaccharides, Bacterial

Identifiers

PMID31001972

DOI10.1021/acsinfecdis.9b00104

PMCPMC6570539

OpenAlexW2939721087

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.