Evidence map›Paper›PMID 31001923›Full record

ArticleThe Kaohsiung journal of medical sciences2019

Protective effects of the suppressed NF-κB/TLR4 signaling pathway on oxidative stress of lung tissue in rat with acute lung injury.

Ze-Ming Zhang, Yan-Cun Wang, Lu Chen, Zheng Li

Open access · goldAbstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  3. Review
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  9. Liraglutide pretreatment attenuates sepsis-induced acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ze-Ming ZhangDepartment of Respiratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Yan-Cun WangDepartment of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Lu ChenDepartment of Respiratory Medicine, The Affiliated Hospital of Hebei University, Baoding, China.
Zheng LiDepartment of Respiratory Medicine, The Affiliated Hospital of Hebei University, Baoding, China.ORCID https://orcid.org/0000-0002-3130-7609
Affiliated Hospital of Hebei University · CNShanghai University of Medicine and Health Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of acute lung injury (ALI) is characterized by lung inflammation and lung oxidative stress. The study was conducted in order to investigate the effect toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) exhibited on oxidative stress in ALI. After the rats had been assigned into different groups, arterial blood, white blood cell (WBC), lung permeability index (LPI), wet/dry (W/D) ratio, TLR4 and NF-κB expression and superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and reactive oxygen species (ROS) were examined. Afterward, the correlation between the levels of TLR4 and NF-κB was determined. Decreased levels of PaO

Indexed as

Acute Lung InjuryAnimalsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsGene Expression RegulationGlutathioneLipopolysaccharidesMalondialdehydeNF-kappa BOxidative StressPeroxidasePyrrolidinesRatsRats, Sprague-DawleyReactive Oxygen SpeciesSignal TransductionAnti-Inflammatory Agents, Non-SteroidalAntioxidantsGlutathioneLipopolysaccharidesMalondialdehydeNF-kappa BPeroxidasepyrrolidine dithiocarbamic acidPyrrolidinesReactive Oxygen SpeciesSuperoxide DismutaseThiocarbamatesTlr4 protein, ratToll-Like Receptor 4acute lung injurylung tissueNF-κB signaling pathwayoxidative stress

Identifiers

PMID31001923
PMCPMC11900739
OpenAlexW2937049433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.