Evidence map›Paper›PMID 31001917›Full record

ArticleCancer medicine2019

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Delores J Grant, Ani Manichaikul, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Lauren C Peres and 80 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

90 authors.

Delores J GrantDepartment of Biological and Biomedical Sciences, Cancer Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina.ORCID 0000-0001-8981-8930
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Anthony J AlbergDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
Elisa V BanderaDepartment of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
Jill Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.ORCID 0000-0001-6190-9304
Melissa BondyCancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, Texas.
Michele L CoteDepartment of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, Michigan.
Ellen FunkhouserDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Patricia G MoormanDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
Lauren C PeresCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Edward S PetersEpidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, Louisisana.
Ann G SchwartzDepartment of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, Michigan.
Paul D TerryDepartment of Medicine, University of Tennessee Medical Center - Knoxville, Knoxville, Tennessee.
Xin-Qun WangDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Temitope O KekuDepartments of Medicine and Nutrition, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Cathrine HoyoDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
Dale P SandlerEpidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Jack A TaylorEpidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Katie M O'BrienEpidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Digna R Velez EdwardsVanderbilt Epidemiology Center, Center for Human Genetics Research, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.
Todd L EdwardsDivision of Epidemiology, Center for Human Genetics Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Alicia Beeghly-FadielDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Celeste Leigh PearceDepartment of Epidemiology, University of Michigan School of, Public Health, Ann Arbor, Michigan.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Alice S WhittemoreDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, California.
Valerie McGuireDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, California.
Weiva SiehDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Joseph H RothsteinDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Francesmary ModugnoDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Roberta NessThe University of Texas School of Public Health, Houston, Texas.
Kirsten MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.ORCID 0000-0002-4678-2058
Mary Anne RossingProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jennifer A DohertyDepartment of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Jennifer B Permuth-WayDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-4726-9264
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Veronica Wendy SetiawanUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Christopher A HaimanUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Loic LeMarchandUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii.
Beth Y KarlanWomen's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Usha MenonMRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
Susan RamusSchool of Women's and Children's Health, University of New South Wales, New South Wales, Australia.
Simon GaytherCenter for Cancer Prevention and Translational Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Aleksandra Gentry-MaharajMRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
Kathryn L TerryObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.
Daniel W CramerObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-8024-3066
Ellen L GoodeDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.
Melissa C LarsonDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
Scott H KaufmannDepartments of Medicine and Pharmacology, Mayo Clinic, Rochester, Minnesota.
Rikki CanniotoCancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York.
Kunle OdunsiDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York.
John L EtterDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
Ruea-Yea HuangCenter For Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York.
Marcus Q BernardiniDivision of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Alicia A ToneDivision of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Taymaa MayDivision of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Pamela J ThompsonCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Michael E CarneyDepartment of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Shelley S TworogerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Elizabeth M PooleBiostatistics, Sanofi Genzyme, Boston, Massachusetts.
Diether LambrechtsVesalius Research Center, VIB, Leuven, Belgium.
Ignace VergoteDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Adriaan VandersticheleDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Els Van NieuwenhuysenDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Hoda Anton-CulverDepartment of Epidemiology, Director of Genetic Epidemiology Research Institute, Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, California.
Argyrios ZiogasDepartment of Epidemiology, University of California Irvine, Irvine, California.
James D BrentonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Helga B SalvensenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Medical Center, Radboud Institute for Molecular Life sciences, Nijmegen, The Netherlands.
Tanja PejovicDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Amanda BrueglDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Melissa MoffittDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Linda CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.
Nhu D LeCancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Linda E KelemenHollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
Paul D P PharoahStrangeways Research laboratory, Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Honglin SongStrangeways Research Laboratory, Department of Oncology, University of Cambridge, Cambridge, UK.
Ian CampbellCancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Victoria, Australia.
Diana EcclesFaculty of Medicine, University of Southampton, Southampton, UK.
Anna DeFazioCentre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Catherine J KennedyCentre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
The FIU Research Center in a Minority Institution (FIU-RCMI)U54MD012393 · NIMHD · FLORIDA INTERNATIONAL UNIVERSITY · PI Shanna L Burke · 2017 to 2026
$32.1M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B., ODUNSI, KUNLE · 2013 to 2025
$19.6M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Novel Serum, Plasma, and Urine Biomarkers of Ovarian CanP50CA105009 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAMER, DANIEL WILLIAM · 2004 to 2010
$13.3M
Cancer Research UK 10119Cancer Research UK 16561Cancer Research UK 22905Cancer Research UK C490/A10119Cancer Research UK C490/A10124Department of HealthNCATS NIH HHS UL1 TR000124NCI NIH HHS K07 CA080668NCI NIH HHS N01 CN025403NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA114343NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA160669NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS U19 CA148112NCI NIH HHS U54 CA156735NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NIEHS NIH HHS Z01 ES044005NIEHS NIH HHS Z01 ES049033NIH HHS S10 OD025170NIMHD NIH HHS U54 MD012393
6 · The paper itself

Abstract

An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10

Indexed as

Bayes TheoremBlack or African AmericanCarcinoma, Ovarian EpithelialErbB ReceptorsFemaleGenetic Association StudiesGlucuronosyltransferaseHumansLogistic ModelsMiddle AgedNeoplasm GradingOvarian NeoplasmsPolymorphism, Single NucleotideReceptors, CalcitriolVitamin DEGFR protein, humanErbB ReceptorsGlucuronosyltransferaseReceptors, CalcitriolUGT2A1 protein, humanVDR protein, humanVitamin DAfrican ancestry riskgenetic associationovarian cancervitamin D pathway

Identifiers

PMID31001917
PMCPMC6536963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.