Evidence map›Paper›PMID 31001915›Full record

ArticleJournal of diabetes2019

Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy.

Sarah R Donnelly, Stefanie N Hinkle, Shristi Rawal, Louise G Grunnet, Jorge E Chavarro, Allan Vaag, Jing Wu, Peter Damm, James L Mills, Mengying Li and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 4 countries.

Sarah R DonnellyEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Stefanie N HinkleEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.ORCID https://orcid.org/0000-0003-4312-708X
Shristi RawalEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Louise G GrunnetDepartment of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen, Denmark.
Jorge E ChavarroHarvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Allan VaagCardiovascular and Metabolic Disease Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Jing WuGlotech, Rockville, Maryland.
Peter DammCenter for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, Copenhagen, Denmark.
James L MillsEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Mengying LiEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.ORCID https://orcid.org/0000-0002-3713-1683
Anne A BjerregaardCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Anne Cathrine B ThuesenDepartment of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen, Denmark.
Robert E Gore-LangtonThe Emmes Corporation, Rockville, Maryland.
Ellen C FrancisEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Sylvia H LeyHarvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Frank B HuHarvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota.
Sjurdur F OlsenCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Cuilin ZhangEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USBrigham and Women's Hospital · USRigshospitalet · DKStatens Serum Institut · DKAstraZeneca (Japan) · JPEmmes (United States) · USGlotech (United States) · USRutgers, The State University of New Jersey · USUniversity of Copenhagen · DKUniversity of Minnesota Medical Center · US

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3M
Diabetes & Women's Health Study: long term health implications of GDMZIAHD008916 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2011 to 2022
$3.3M
'Centre for Fetal Programming', The Health Foundation 11/263-96Danish Diabetes AcademyEunice Kennedy Shriver National Institute of Child Health and Human Development HSN275201100002IEuropean Union FP7-289346Heart Foundation 96-2-4-83-22450Innovation Fund Denmark 09-67124Innovation Fund Denmark 11-115923Intramural NIH HHS ZIA HD008916March of Dimes Birth Defects Foundation 6-FY00-407March of Dimes Birth Defects Foundation 6-FY-96-0240March of Dimes Birth Defects Foundation 6-FY97-0521March of Dimes Birth Defects Foundation 6-FY97-0553NICHD NIH HHS HHSN275201000020CNICHD NIH HHS HHSN275201300026INICHD NIH HHS HHSN275201500003CNIGMS NIH HHS P20 GM109036Novo Nordisk Foundation
6 · The paper itself

Abstract

backgroundWomen with gestational diabetes mellitus (GDM) may be at an increased risk of liver complications because chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking.

methodsThe Diabetes & Women's Health Study (2012-2014) examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort. Nine to 16 years postpartum, a clinical examination was performed, with measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, from which fatty liver scoring indices were calculated to assess liver fat score, fatty liver index, hepatic steatosis index, and liver fat percentage. Relative risks (RR) with 95% confidence intervals (CI) for elevated liver scoring indices by GDM status were assessed adjusting for major risk factors, including prepregnancy body mass index.

resultsWomen with prior GDM had higher adjusted ALT and AST levels than women without GDM (by 6.7% [95% CI 1.7-12.0] and 4.8% [95% CI 0.6-9.1], respectively). Women with GDM also had adjusted increased risks for elevated liver fat score (RR 2.34; 95% CI 1.68-3.27), fatty liver index (RR 1.59; 95% CI 1.27-1.99), and hepatic steatosis index (RR 1.44; 95% CI 1.21-1.71).

conclusionsWomen with GDM during pregnancy were at an increased risk for fatty liver 9 to 16 years postpartum. Gestational diabetes mellitus may serve as another risk indicator for the early identification and prevention of liver fat accumulation.

Indexed as

AdultAlanine TransaminaseAspartate AminotransferasesBiomarkersBody Mass IndexDenmarkDiabetes, GestationalFatty LiverFemaleFollow-Up StudiesHumansLongitudinal StudiesPregnancyPrognosisProspective StudiesRisk FactorsAlanine TransaminaseAspartate AminotransferasesBiomarkersfatty livergestational diabeteshyperglycemialiver fat scoring indicespregnancy妊娠妊娠糖尿病肝脏脂肪评分指标脂肪肝高血糖

Identifiers

PMID31001915
PMCPMC6791726
OpenAlexW2935904657

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.