Evidence map›Paper›PMID 31001800›Full record

ArticleEndocrine pathology2019

A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma.

Nada A Farhat, James F Powers, Annette Shepard-Barry, Patricia Dahia, Karel Pacak, Arthur S Tischler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Pilot study: transduction of primary paraganglioma chromaffin tumour cells with inducible c-MYC drives cell proliferation.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nada A FarhatNew York Eye and Ear Infirmary of Mount Sinai Icahn School of Medicine, New York, NY, USA.
James F PowersDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Box 802, Boston, MA, 02111, USA. jpowers1@tuftsmedicalcenter.org.
Annette Shepard-BarryDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Box 802, Boston, MA, 02111, USA.
Patricia DahiaDepartment of Medicine and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.
Karel PacakSection on Medical Neuroendocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Arthur S TischlerDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Box 802, Boston, MA, 02111, USA.
Tufts Medical Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNew York Eye and Ear Infirmary · USThe University of Texas Health Science Center at San Antonio · US

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complexR01GM114102 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAHIA, PATRICIA LEAL · 2017 to 2021
$1.5M
Intramural NIH HHS ZIA HD008735NIGMS NIH HHS R01 GM114102
6 · The paper itself

Abstract

We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be more numerous. These cells frequently resemble sustentacular cells topographically and cytologically, possibly explaining why they have not been previously noticed. They contribute to the tumor proteome and may have implications for tumor biology. No correlations were identifiable between the presence of these cells and any clinical characteristics of the tumors in the present study. A possible association with genotype is suggested by immunoblot showing high expression of CD163 protein in tumors with succinate dehydrogenase mutations.

Indexed as

Adrenal Gland NeoplasmsAdultAgedAged, 80 and overAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenFemaleHumansImmunohistochemistryMaleMiddle AgedMonocytesMutationParagangliomaPheochromocytomaAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenReceptors, Cell SurfaceS100 ProteinsSDHD protein, humanSuccinate DehydrogenaseImmunohistochemistryMacrophageMonocyteParagangliomaPheochromocytomaSustentacular cell

Identifiers

PMID31001800
PMCPMC6816458
OpenAlexW2938155060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.