ArticleObesity surgery2019
Genetic Determinants of Weight Loss After Bariatric Surgery.
Article in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.Current obesity reports · 2023Pooled it
- A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery.Obesity surgery · 2021Pooled it
- Polygenic Score for Body Mass Index Is Associated with Weight Loss and Lipid Outcomes After Metabolic and Bariatric Surgery.International journal of molecular sciences · 2025Article
- Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery.Nature medicine · 2025Article
- Optimizing Nutritional Management Before and After Bariatric Surgery: A Comprehensive Guide for Sustained Weight Loss and Metabolic Health.Nutrients · 2025Review
- Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks.medRxiv : the preprint server for health sciences · 2025Article
- Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review.Frontiers in public health · 2025Review
- Does Patient's Metabolic and Bariatric Surgery Knowledge Predict Optimal Clinical Outcomes?Obesity surgery · 2024Article
- Longitudinal Profiling of Fasting Plasma Metabolome in Response to Weight-Loss Interventions in Patients with Morbid Obesity.Metabolites · 2024Article
- Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake.International journal of obesity (2005) · 2023Article
- Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery.Journal of clinical medicine · 2023Article
- Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery.Obesity surgery · 2023Article
- A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study.Journal of personalized medicine · 2021Article
- Factors Affecting Metabolic Outcomes Post Bariatric Surgery: Role of Adipose Tissue.Journal of clinical medicine · 2021Review
- Article
- Does Postoperative Oral and Intestinal Microbiota Correlate with the Weight-Loss Following Bariatric Surgery?-A Cohort Study.Journal of clinical medicine · 2020Article
- Impact of weight trajectory after bariatric surgery on co-morbidity evolution and burden.BMC health services research · 2020Article
- A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery.Obesity surgery · 2020Article
- Preoperative considerations for the pediatric patient undergoing metabolic and bariatric surgery.Seminars in pediatric surgery · 2020Review
- Comparison of Comorbidity Treatment and Costs Associated With Bariatric Surgery Among Adults With Obesity in Canada.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.
methodsPatients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.
resultsThe average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression. DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.
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