Evidence map›Paper›PMID 31001717›Full record

ReviewPharmaceutical research2019

Challenges and Opportunities for Patient Centric Drug Product Design: Industry Perspectives.

Matthew D Burke, Melissa Keeney, Rochelle Kleinberg, Rubi Burlage

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmaceutical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew D BurkeGlaxoSmithKline, 1250 South Collegeville Rd, Collegeville, PA, 19426, USA. matthew.d.burke@gsk.com.ORCID http://orcid.org/0000-0001-6782-3827
Melissa KeeneyEli Lilly and Company, Indianapolis, IN, 46285, USA.
Rochelle KleinbergJohnson and Johnson, 601 W 26th Street, Suite 1601, New York, NY, 10001, USA.
Rubi BurlageMerck Research Laboratories, Kenilworth, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For an industry dedicated to preventing and treating disease, the concept of patient centric drug product design is remarkably new, yet it is beginning to transform medicinal development. The paternalistic paradigm of delivering efficacious and safe medicinal products, with inconsistent emphasis on patient centric considerations, is no longer sufficient. Patient expectations have evolved, and treatment use must complement patients' daily lives. While designing medicines to facilitate patients' use is now expected, the patient diversity across sub-populations and markets as well as industrial factors such as physicochemical properties, supply chain and shelf life aspects may preclude the development of a single, universal patient centric solution that meets all the needs of those with a particular disease. The objective of this publication is to highlight the complexities of implementing patient centric drug product design through a hypothetical HIV case study using the existing development and business processes to raise awareness and to suggest opportunities for collaboration.

Indexed as

Anti-HIV AgentsChemistry, PharmaceuticalDosage FormsDrug CompoundingDrug DesignDrug IndustryHIVHumansTreatment OutcomeAnti-HIV AgentsDosage Formsdosage form designdrug product designpatient centricpatient focused drug developmentpatient insights

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.