ArticleScience advances2019
A 192-heme electron transfer network in the hydrazine dehydrogenase complex.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Lysine or histidine? examining the role of the proximal ligand at the active heme center of cytochrome c nitrite reductase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Origin and Evolution of Key Enzymes in the Anammox Pathway Revisited.Genome biology and evolution · 2026Article
- A Biomimetic Twisting Strategy Enables Efficient Electrocatalytic Oxidation of Energy-Dense Hydrazine Hydrate on FeNJournal of the American Chemical Society · 2025Article
- The iron metalloproteome of Pseudomonas aeruginosa under oxic and anoxic conditions.Metallomics : integrated biometal science · 2025Article
- A new heme enzyme family forms hydrazine groups in diverse biosynthetic pathways.bioRxiv : the preprint server for biology · 2025Article
- A powerful but frequently overlooked role of thermodynamics in environmental microbiology: inspirations from anammox.Applied and environmental microbiology · 2025Review
- Cytochrome "nanowires" are physically limited to sub-picoamp currents that suffice for cellular respiration.Frontiers in chemistry · 2025Article
- Fractionating proteins with nitrite-reducing activity in "Frontiers in microbiology · 2025Article
- A survey of the Desulfuromonadia "cytochromome" provides a glimpse of the unexplored diversity of multiheme cytochromes in nature.BMC genomics · 2024Article
- Copper sulfide mineral performs non-enzymatic anaerobic ammonium oxidation through a hydrazine intermediate.Nature chemistry · 2024Article
- Microbial divergence and evolution. The case of anammox bacteria.Frontiers in microbiology · 2024Article
- Article
- Light-driven ammonium oxidation to dinitrogen gas by self-photosensitized biohybrid anammox systems.iScience · 2023Article
- Phylogenomic Evidence for the Origin of Obligate Anaerobic Anammox Bacteria Around the Great Oxidation Event.Molecular biology and evolution · 2022Article
- Nature's nitrite-to-ammonia expressway, with no stop at dinitrogen.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Review
- Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex.Nature microbiology · 2021Article
- Specificity of SmallACS omega · 2021Article
- Protein-Embedded Metalloporphyrin Arrays Templated by Circularly Permuted Tobacco Mosaic Virus Coat Proteins.ACS nano · 2021Article
- Biological and Bioinspired Inorganic N-N Bond-Forming Reactions.Chemical reviews · 2020Review
- Role of multiheme cytochromes involved in extracellular anaerobic respiration in bacteria.Protein science : a publication of the Protein Society · 2020Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaerobic ammonium oxidation (anammox) is a major process in the biogeochemical nitrogen cycle in which nitrite and ammonium are converted to dinitrogen gas and water through the highly reactive intermediate hydrazine. So far, it is unknown how anammox organisms convert the toxic hydrazine into nitrogen and harvest the extremely low potential electrons (-750 mV) released in this process. We report the crystal structure and cryo electron microscopy structures of the responsible enzyme, hydrazine dehydrogenase, which is a 1.7 MDa multiprotein complex containing an extended electron transfer network of 192 heme groups spanning the entire complex. This unique molecular arrangement suggests a way in which the protein stores and releases the electrons obtained from hydrazine conversion, the final step in the globally important anammox process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.