ArticleScience advances2019
Imaging localized neuronal activity at fast time scales through biomechanics.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions.Cells · 2026Review
- 40 Years of diffusion MRI in the brain: From history to emerging frontiers.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Brain mechanics and cognition: the role of rodent MR elastography in identifying cellular mechanisms.Frontiers in cognition · 2026Article
- Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Displacement and functional ultrasound (fUS) imaging of displacement-guided focused ultrasound (FUS) neuromodulation in mice.NeuroImage · 2024Article
- Making sense of scattering: Seeing microstructure through shear waves.Science advances · 2024Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Functional ultrasound (fUS) imaging of displacement-guided focused ultrasound (FUS) neuromodulation in mice.bioRxiv : the preprint server for biology · 2024Article
- Mechanical behavior and microstructure of porcine brain tissues under pulsed electric fields.Biomechanics and modeling in mechanobiology · 2024Article
- Performance reserves in brain-imaging-based phenotype prediction.Cell reports · 2024Article
- Functional MR elastography measures visual cortex stiffening proportional to visual contrast intensity in regions of activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents.Scientific reports · 2023Article
- Ultra-wideband optical coherence elastography from acoustic to ultrasonic frequencies.Nature communications · 2023Article
- Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.PloS one · 2023Article
- Initial experiences with Direct Imaging of Neuronal Activity (DIANA) in humans.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Theory of sleep/wake cycles affecting brain elastography.Physics in medicine and biology · 2022Article
- Mechanical properties of murine hippocampal subregions investigated by atomic force microscopy and in vivo magnetic resonance elastography.Scientific reports · 2022Article
- Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions.Frontiers in bioengineering and biotechnology · 2022Article
- A MinireviewFrontiers in bioengineering and biotechnology · 2022Review
- Cerebral stiffness changes during visual stimulation: Differential physiological mechanisms characterized by opposing mechanical effects.Neuroimage. Reports · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Mapping neuronal activity noninvasively is a key requirement for in vivo human neuroscience. Traditional functional magnetic resonance (MR) imaging, with a temporal response of seconds, cannot measure high-level cognitive processes evolving in tens of milliseconds. To advance neuroscience, imaging of fast neuronal processes is required. Here, we show in vivo imaging of fast neuronal processes at 100-ms time scales by quantifying brain biomechanics noninvasively with MR elastography. We show brain stiffness changes of ~10% in response to repetitive electric stimulation of a mouse hind paw over two orders of frequency from 0.1 to 10 Hz. We demonstrate in mice that regional patterns of stiffness modulation are synchronous with stimulus switching and evolve with frequency. For very fast stimuli (100 ms), mechanical changes are mainly located in the thalamus, the relay location for afferent cortical input. Our results demonstrate a new methodology for noninvasively tracking brain functional activity at high speed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.