ArticleBehavioural neurology2019
Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis.
Article in Behavioural neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Oculomotor atypicalities in motor neurone disease: a systematic review.Frontiers in neuroscience · 2024Pooled it
- Data-driven disease subgrouping in ALS: a multicenter cerebral functional connectivity study.Journal of neurology · 2026Article
- Longitudinal analysis of brain functional connectivity and its association with clinical assessment in depressed patients using resting state fMRI.Scientific reports · 2025Article
- Review
- Effects of Transcranial Direct Current Stimulation on Graph Naming Function and Brain Connectivity in Postinfarction Aphasia Patients: An fMRI Study.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2024Article
- T1-weighted MRI texture analysis in amyotrophic lateral sclerosis patients stratified by the D50 progression model.Brain communications · 2024Article
- The Spectrum of Cognitive Dysfunction in Amyotrophic Lateral Sclerosis: An Update.International journal of molecular sciences · 2023Review
- Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders.Neurology · 2021Article
- Emotional Processing and Experience in Amyotrophic Lateral Sclerosis: A Systematic and Critical Review.Brain sciences · 2021Review
- Cognitive and Behavioral Manifestations in ALS: Beyond Motor System Involvement.Diagnostics (Basel, Switzerland) · 2021Review
- Electrical and Hemodynamic Neural Functions in People With ALS: An EEG-fNIRS Resting-State Study.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Reliability and validity of speech & pause measures during passage reading in ALS.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS). 17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging. Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades. The measure of speaking rate represented bulbar motor changes. Neuroanatomical assessment was performed using volumetric analyses focused on frontal lobe regions, postcentral gyrus, and occipital lobes as controls. Partial least square regressions (PLS) were used to predict behavioral (cognitive and speech rate) outcomes using volumetric measures. The data supported the overall hypothesis that distinct behavioral changes in cognition and speaking rate in ALS were related to specific regional neurostructural brain changes. These changes did not support a notion of a general dysexecutive syndrome in ALS. The observed specificity of behavior-brain changes can begin to provide a framework for subtyping of ALS. The data also support a more integrative framework for clinical assessment of frontal lobe functioning in ALS, which requires both behavioral testing and neuroimaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.