Evidence map›Paper›PMID 31001242›Full record

ArticleFrontiers in microbiology2019

Application of a Dual Internally Quenched Fluorogenic Substrate in Screening for D-Arginine Specific Proteases.

Andreas H Simon, Sandra Liebscher, Tobias H Aumüller, Dennis Treblow, Frank Bordusa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Multicyclic D-Stereospecific Hydrolase Dimer With High Sustained Activity.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. The Impact ofAnimals : an open access journal from MDPI · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andreas H SimonInstitute of Biochemistry/Biotechnology, Charles Tanford Protein Centre, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Sandra LiebscherInstitute of Biochemistry/Biotechnology, Charles Tanford Protein Centre, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Tobias H AumüllerMax Planck Research Unit for Enzymology of Protein Folding, Halle, Germany.
Dennis TreblowInstitute of Biochemistry/Biotechnology, Charles Tanford Protein Centre, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Frank BordusaInstitute of Biochemistry/Biotechnology, Charles Tanford Protein Centre, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Martin Luther University Halle-Wittenberg · DEMax Planck Research Unit for Enzymology of Protein Folding · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of D-stereospecific proteases (DSPs) in resolution of racemic amino acids and in the semisynthesis of proteins has been a successful strategy. The main limitation for a broader application is, however, the accessibility of suitable DSPs covering multiple substrate specificities. To identify DSPs with novel primary substrate preferences, a fast specificity screening method using the easily accessible internally quenched fluorogenic substrate aminobenzoyl-D-arginyl-D-alanyl-

Indexed as

D-amino acidsD-arginineDD-peptidasesinternally quenched fluorogenic substratespenicillin binding proteinsproteasesscreening

Identifiers

PMID31001242
PMCPMC6456654
OpenAlexW2929551524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.