Evidence map›Paper›PMID 31001234›Full record

ArticleFrontiers in microbiology2019

Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent

Joerg Jores, Li Ma, Paul Ssajjakambwe, Elise Schieck, Anne Liljander, Suchismita Chandran, Michael H Stoffel, Valentina Cippa, Yonathan Arfi, Nacyra Assad-Garcia and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. iScience · 2026
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  10. Comparative genomics ofMicrobial genomics · 2023
    Article
  11. Article
  12. Genome Engineering of the Fast-GrowingACS synthetic biology · 2022
    Article
  13. Article
  14. Article
  15. Advances in Enhanced Menaquinone-7 Production FromFrontiers in bioengineering and biotechnology · 2021
    Review
  16. Review
  17. Review
  18. ACS synthetic biology · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 5 countries.

Joerg JoresDepartment of Infectious Diseases and Pathobiology, Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
Li MaJ. Craig Venter Institute, Rockville, MD, United States.
Paul SsajjakambweInternational Livestock Research Institute, Nairobi, Kenya.
Elise SchieckInternational Livestock Research Institute, Nairobi, Kenya.
Anne LiljanderInternational Livestock Research Institute, Nairobi, Kenya.
Suchismita ChandranJ. Craig Venter Institute, Rockville, MD, United States.
Michael H StoffelDivision of Veterinary Anatomy, Department of Clinical Research and Veterinary Public Health, University of Bern, Bern, Switzerland.
Valentina CippaDepartment of Infectious Diseases and Pathobiology, Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
Yonathan ArfiUMR 1332 - Biologie du Fruit et Pathologie, Institut National de la Recherche Agronomique, Villenave-d'Ornon, France.
Nacyra Assad-GarciaJ. Craig Venter Institute, Rockville, MD, United States.
Laurent FalquetBiochemistry Unit, Swiss Institute of Bioinformatics, University of Fribourg, Fribourg, Switzerland.
Pascal Sirand-PugnetUMR 1332 - Biologie du Fruit et Pathologie, Institut National de la Recherche Agronomique, Villenave-d'Ornon, France.
Alain BlanchardUMR 1332 - Biologie du Fruit et Pathologie, Institut National de la Recherche Agronomique, Villenave-d'Ornon, France.
Carole LartigueUMR 1332 - Biologie du Fruit et Pathologie, Institut National de la Recherche Agronomique, Villenave-d'Ornon, France.
Horst PosthausDepartment for Infectious Diseases and Pathobiology, Institute of Animal Pathology (COMPATH), University of Bern, Bern, Switzerland.
Fabien LabroussaaDepartment of Infectious Diseases and Pathobiology, Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
Sanjay VasheeJ. Craig Venter Institute, Rockville, MD, United States.
University of Bern · CHJ. Craig Venter Institute · USUniversité de Bordeaux · FRInternational Livestock Research Institute · KEBiologie du Fruit et Pathologie · FRMakerere University · UGUniversity of Fribourg · CH

Funding

Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2
6 · The paper itself

Abstract

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent

Indexed as

attenuationgenome engineeringin vivo challengeMycoplasma mycoides subsp. caprivirulence traits

Identifiers

PMID31001234
PMCPMC6456743
OpenAlexW2949543170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.