Evidence map›Paper›PMID 31001192›Full record

ArticleFrontiers in neurology2019

Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis.

Tina Fuchs, Kerstin Puellmann, David H Dreyfus, Armin P Piehler, Björn Reuter, Christopher Schwarzbach, Olaf Willmann, Diego Yepes, Victor Costina, Peter Findeisen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Tina FuchsInstitute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kerstin PuellmannAesculabor Hamburg, Hamburg, Germany.
David H DreyfusDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, United States.
Armin P PiehlerBioscientia Institute for Medical Diagnostics, Karlsfeld, Germany.
Björn ReuterDepartment of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Christopher SchwarzbachDepartment of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Olaf WillmannDepartment of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Diego YepesInstitute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Victor CostinaInstitute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Peter FindeisenInstitute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Jens MahrtMolecular & Optical Live Cell Imaging, University of Göttingen, Göttingen, Germany.
Chunlin WangiRepertoire Inc., Huntsville, AL, United States.
Jian HaniRepertoire Inc., Huntsville, AL, United States.
Alexander W BehamDepartment of Surgery, Hospital of Siegen, Siegen, Germany.
Michael NeumaierInstitute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Wolfgang E KaminskiBioscientia Institute for Medical Diagnostics, Ingelheim, Germany.
University Hospital Heidelberg · DEUniversity Medical Centre Mannheim · DEHeidelberg University · DEiRepertoire (United States) · USUniversity of Göttingen · DEUniversity of Siegen · DEYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial meningitis is a life-threatening disease that evokes an intense neutrophil-dominated host response to microbes invading the subarachnoid space. Recent evidence indicates the existence of combinatorial V(D)J immune receptors in neutrophils that are based on the T cell receptor (TCR). Here, we investigated expression of the novel neutrophil TCRαβ-based V(D)J receptors in cerebrospinal fluid (CSF) from human patients with acute-phase bacterial meningitis using immunocytochemical, genetic immunoprofiling, cell biological, and mass spectrometric techniques. We find that the human neutrophil combinatorial V(D)J receptors are rapidly induced in CSF neutrophils during the first hours of bacterial meningitis. Immune receptor repertoire diversity is consistently increased in CSF neutrophils relative to circulating neutrophils and phagocytosis of baits directed to the variable immunoreceptor is enhanced in CSF neutrophils during acute-phase meningitis. Our results reveal that a flexible immune response involving neutrophil V(D)J receptors which enhance phagocytosis is immediately initiated at the site of acute bacterial infection.

Indexed as

bacterial meningitisneutrophil granulocytesphagocytosisT cell receptorsV(D)J receptors

Identifiers

PMID31001192
PMCPMC6454057
OpenAlexW2933968642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.