ReviewFrontiers in psychology2019
Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit.
Review in Frontiers in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Indicators of maternal anxiety, stress, and depression and developmental outcomes in preterm children: A systematic review.Infant mental health journal · 2026Pooled it
- Mothers' Views and Experiences of Digital Maternal Presence Intervention and Skin-to-Skin Contact for Neonatal Pain Relief: A Qualitative Study.Nursing open · 2026Observational
- Repetitive daily oxytocin treatment reduces weight gain but not acute neonatal procedural pain.Pediatric research · 2025Article
- Maternal singing and speech have beneficial effects on preterm infant's general movements at term equivalent age and at 3 months: an RCT.Frontiers in psychology · 2025Article
- The Effect of Maternal Oxytocin Induction during Birth on Early Neonatal Pain and Stress: A Quasi-Experimental Study.Biological research for nursing · 2025Article
- Enhancing Sensory Experiences for Infants Born Preterm: A Quality Improvement Project.Archives of rehabilitation research and clinical translation · 2024Review
- Alleviating Neonatal Intensive Care Unit Stress: A Chinese Medicine Approach in Neonatal Rats.BioMed research international · 2024Article
- Parent-led neonatal pain management-a narrative review and update of research and practices.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Maternal Voice and Tactile Stimulation Modulate Oxytocin in Mothers of Hospitalized Preterm Infants: A Randomized Crossover Trial.Children (Basel, Switzerland) · 2023Article
- Parental involvement in postoperative pain management among children in a urology ward: A best practice implementation project.Nursing open · 2023Article
- Regional anesthesia for pain control in children with solid tumors-a review of case reports.Frontiers in pediatrics · 2023Article
- The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation.Cells · 2022Review
- Parental Book-Reading to Preterm Born Infants in NICU: The Effects on Language Development in the First Two Years.International journal of environmental research and public health · 2021Article
- Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures.Scientific reports · 2021Article
- Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia.Seminars in fetal & neonatal medicine · 2021Review
- Psychosocial and Neurobiological Vulnerabilities of the Hospitalized Preterm Infant and Relevant Non-pharmacological Pain Mitigation Strategies.Frontiers in pediatrics · 2021Review
- Technical Innovation for Visual Assessment of Preterm Newborns in a Neonatal Intensive Care Unit: Exploratory Study.Rehabilitation research and practice · 2021Article
- Skin-to-Skin Care by Mother vs. Father for Preterm Neonatal Pain: A Randomized Control Trial (ENVIRON Trial).International journal of pediatrics · 2021Article
- Study protocol: parents as pain management in Swedish neonatal care - SWEpap, a multi-center randomized controlled trial.BMC pediatrics · 2020Article
- [Research advances in the effect of environmental stress in the neonatal intensive care unit on the neurodevelopment of preterm infants and its epigenetics].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm infants (PTI) typically experience many painful and stressful procedures or events during their first weeks of life in a neonatal intensive care unit, and these can profoundly impact subsequent brain development and function. Several protective interventions during this sensitive period stimulate the oxytocin system, reduce pain and stress, and improve brain development. This review provides an overview of the environmental risk factors experienced by PTI during hospitalization, with a focus on the effects of pain, and early maternal separation. We also describe the long-term adverse effects of the simultaneous experiences of pain and maternal separation, and the potential beneficial effects of maternal vocalizations, parental contact, and several related processes, which appear to be mediated by the oxytocin system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.