ArticleFrontiers in psychology2019
Cognitive Profiles and Functional Connectivity in First-Episode Schizophrenia Spectrum Disorders - Linking Behavioral and Neuronal Data.
Article in Frontiers in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- The role of the globus pallidus subregions in the schizophrenia spectrum continuum.Molecular psychiatry · 2026Article
- Accelerated DMN-targeted cTBS improves processing speed deficits in schizophrenia.Molecular psychiatry · 2026Article
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Accelerated DMN-Targeted cTBS Improves Processing Speed Deficits in Schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia.Current neurology and neuroscience reports · 2023Review
- Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.Schizophrenia (Heidelberg, Germany) · 2023Article
- Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?The European journal of neuroscience · 2023Review
- Smoking and attention in schizophrenia spectrum disorders: What are we neglecting?Frontiers in psychology · 2023Article
- Impaired large-scale cortico-hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia.Frontiers in neuroscience · 2023Article
- Triple-Network Dysconnectivity in Patients With First-Episode Psychosis and Individuals at Clinical High Risk for Psychosis.Psychiatry investigation · 2022Article
- Relating self-disorders to neurocognitive and psychopathological measures in first-episode schizophrenia.Early intervention in psychiatry · 2022Article
- Identifying and revealing different brain neural activities of cognitive subtypes in early course schizophrenia.Frontiers in molecular neuroscience · 2022Article
- The screen for cognitive impairment in psychiatry (SCIP) as a routinely applied screening tool: pathology of acute psychiatric inpatients and cluster analysis.BMC psychiatry · 2021Article
- Heterogeneity of Outcomes and Network Connectivity in Early-Stage Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2021Article
- The Performance of Visual Perceptual Tasks in Patients with Schizotypal Personality Disorder.Psychology in Russia : state of the art · 2021Article
- Verbal memory measurement towards digital perspectives in first-episode psychosis: A review.Schizophrenia research. Cognition · 2020Review
- Examining Specificity of Neural Correlates of Childhood Psychotic-like Experiences During an Emotional n-Back Task.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Adjunct ketamine treatment of depression in treatment-resistant schizophrenia patients is unsatisfactory in pilot and secondary follow-up studies.Brain and behavior · 2020Article
- Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings.Frontiers in psychiatry · 2019Article
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12 authors.
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Abstract
The character of cognitive deficit in schizophrenia is not clear due to the heterogeneity in research results. In heterogeneous conditions, the cluster solution allows the classification of individuals based on profiles. Our aim was to examine the cognitive profiles of first-episode schizophrenia spectrum disorder (FES) subjects based on cluster analysis, and to correlate these profiles with clinical variables and resting state brain connectivity, as measured with magnetic resonance imaging. A total of 67 FES subjects were assessed with a neuropsychological test battery and on clinical variables. The results of the cognitive domains were cluster analyzed. In addition, functional connectivity was calculated using ROI-to-ROI analysis with four groups: Three groups were defined based on the cluster analysis of cognitive performance and a control group with a normal cognitive performance. The connectivity was compared between the patient clusters and controls. We found different cognitive profiles based on three clusters: Cluster 1: decline in the attention, working memory/flexibility, and verbal memory domains. Cluster 2: decline in the verbal memory domain and above average performance in the attention domain. Cluster 3: generalized and severe deficit in all of the cognitive domains. FES diagnoses were distributed among all of the clusters. Cluster comparisons in neural connectivity also showed differences between the groups. Cluster 1 showed both hyperconnectivity between the cerebellum and precentral gyrus, the salience network (SN) (insula cortex), and fronto-parietal network (FPN) as well as between the PreCG and SN (insula cortex) and hypoconnectivity between the default mode network (DMN) and seeds of SN [insula and supramarginal gyrus (SMG)]; Cluster 2 showed hyperconnectivity between the DMN and cerebellum, SN (insula) and precentral gyrus, and FPN and IFG; Cluster 3 showed hypoconnectivity between the DMN and SN (insula) and SN (SMG) and pallidum. The cluster solution confirms the prevalence of a cognitive decline with different patterns of cognitive performance, and different levels of severity in FES. Moreover, separate behavioral cognitive subsets can be linked to patterns of brain functional connectivity.
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