Evidence map›Paper›PMID 31001108›Full record

ArticleFrontiers in aging neuroscience2019

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer's Disease.

Laurent Younes, Marilyn Albert, Abhay Moghekar, Anja Soldan, Corinne Pettigrew, Michael I Miller

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
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  7. Predicting Future Brain Atrophy Based on Longitudinal MRI.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laurent YounesDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, United States.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Anja SoldanDepartment of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Corinne PettigrewDepartment of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Michael I MillerDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, United States.

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2014 to 2026
$51.5M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Neurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8M
PREDICT-ADFTD: Multimodal Imaging Prediction of AD/FTD and Differential DiagnosisR01AG055121 · NIA · OHIO STATE UNIVERSITY · PI ROSEN, HOWARD J, WANG, LEI · 2017 to 2020
$2.8M
3D Shape Analysis for Computational AnatomyR01EB008171 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I · 2009 to 2012
$2.0M
NIA NIH HHS P50 AG005146
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkerschangepointscognitive assessmentCSF assessmentpreclinical Alzheimer’s diseaseshape analysis

Identifiers

PMID31001108
PMCPMC6454004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.