Evidence map›Paper›PMID 31001088›Full record

ArticleFrontiers in cellular neuroscience2019

Meningeal Mast Cells as Key Effectors of Stroke Pathology.

Ahmet Arac, Michele A Grimbaldeston, Stephen J Galli, Tonya M Bliss, Gary K Steinberg

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Review
  4. Article
  5. Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Investigating theOxidative medicine and cellular longevity · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Neuroimmunology of depression.Advances in pharmacology (San Diego, Calif.) · 2021
    Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ahmet AracDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Michele A GrimbaldestonOMNI-Biomarker Development, Genentech Inc., South San Francisco, CA, United States.
Stephen J GalliDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA, United States.
Tonya M BlissDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Gary K SteinbergDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Stanford University · USUniversity of California, Los Angeles · US

Funding

Transgenic animal injury paradigmsP01NS037520 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 1999 to 2008
$10.8M
Role of Mast Cells in Inflammation and ImmunityR01CA072074 · NCI · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 1996 to 2010
$4.4M
Translational Neuroscience Training GrantR25NS065723 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS · 2009 to 2023
$2.8M
Expression and Modulation of Mast Cell Function in AsthmaR01AI070813 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2006 to 2010
$2.5M
Regulation of Mast Cell Development and FunctionR01AI023990 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 1986 to 2010
$2.4M
REGULATION OF MAST CELL DEVELOPMENT &FUNCTIONR37AI023990 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN J · 1996 to 2005
$2.2M
UCLA Neuroscience Physician-Scientist Training ProgramUE5NS065723 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Stanley Thomas Carmichael, Jason D Hinman · 2024 to 2026
$1.2M
Motor cortex network dynamics driving stroke recoveryK08NS109315 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARAC, AHMET · 2018 to 2022
$1.1M
Meningeal Mast Cells: Key effectors of stroke pathologyR21NS080062 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2013 to 2014
$431k
NCI NIH HHS R01 CA072074NIAID NIH HHS R01 AI023990NIAID NIH HHS R01 AI070813NIAID NIH HHS R37 AI023990NINDS NIH HHS K08 NS109315NINDS NIH HHS P01 NS037520NINDS NIH HHS R21 NS080062NINDS NIH HHS R25 NS065723NINDS NIH HHS UE5 NS065723
6 · The paper itself

Abstract

Stroke is the leading cause of adult disability in the United States. Because post-stroke inflammation is a critical determinant of damage and recovery after stroke, understanding the interplay between the immune system and the brain after stroke holds much promise for therapeutic intervention. An understudied, but important aspect of this interplay is the role of meninges that surround the brain. All blood vessels travel through the meningeal space before entering the brain parenchyma, making the meninges ideally located to act as an immune gatekeeper for the underlying parenchyma. Emerging evidence suggests that the actions of immune cells resident in the meninges are essential for executing this gatekeeper function. Mast cells (MCs), best known as proinflammatory effector cells, are one of the long-term resident immune cells in the meninges. Here, we discuss recent findings in the literature regarding the role of MCs located in the meningeal space and stroke pathology. We review the latest advances in mouse models to investigate the roles of MCs and MC-derived products

Indexed as

ischemic strokemast cellsmeningeal mast cellsmeningesstroke pathology

Identifiers

PMID31001088
PMCPMC6457367
OpenAlexW2929439854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.