Evidence map›Paper›PMID 31001077›Full record

ArticleFrontiers in neuroscience2019

Novel Calibrated Short TR Recovery (CaSTRR) Method for Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast in Blood Flow Measurements in Mice.

Scott W Thalman, David K Powell, Ai-Ling Lin

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In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Scott W ThalmanF. Joseph Halcomb III, MD Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States.
David K PowellF. Joseph Halcomb III, MD Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States.
Ai-Ling LinF. Joseph Halcomb III, MD Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States.

Funding

A High-Field Small Animal MR Imager for Biomedical ResearchS10RR029541 · NCRR · UNIVERSITY OF KENTUCKY · PI SMITH, CHARLES DENNIS · 2010 to 2010
$3.1M
Multi-Modal MRI to Assess Alzheimer's Disease Prevention in an APOE4 MouseModelR01AG054459 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIN, AI-LING · 2017 to 2021
$3.0M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG057461 · NIA · UNIVERSITY OF KENTUCKY · PI MURPHY, MICHAEL PAUL, VAN ELDIK, LINDA J · 2017 to 2021
$2.1M
Neuroimaging Assessments of Brain Integrity in Aging MiceK01AG040164 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LIN, AI-LING · 2012 to 2016
$462k
NCRR NIH HHS S10 RR029541NIA NIH HHS K01 AG040164NIA NIH HHS R01 AG054459NIA NIH HHS T32 AG057461
6 · The paper itself

Abstract

The goal of the study was to develop a novel, rapid Calibrated Short TR Recovery (CaSTRR) method to measure the brain-blood partition coefficient (BBPC) in mice. The BBPC is necessary for quantifying cerebral blood flow (CBF) using tracer-based techniques like arterial spin labeling (ASL), but previous techniques required prohibitively long acquisition times so a constant BBPC equal to 0.9 mL/g is typically used regardless of studied species, condition, or disease. An accelerated method of BBPC correction could improve regional specificity in CBF maps particularly in white matter. Male C57Bl/6N mice (

Indexed as

arterial spin labelingbrain-blood partition coefficientcerebral blood flowgray-white matter contrastmagnetic resonance imaging

Identifiers

PMID31001077
PMCPMC6454029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.