ArticleFrontiers in neuroscience2019
Low-Intensity Pulsed Ultrasound Stimulation Modulates the Nonlinear Dynamics of Local Field Potentials in Temporal Lobe Epilepsy.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 33 citations in OpenAlex.
- High pressure transcranial focused ultrasound stimulation induces parameter-dependent cell-type specific effects.Microsystems & nanoengineering · 2026Review
- Channel-specific differential effects of bacterial mechanosensitive channels for ultrasound neuromodulation in precision sonogenetics.Theranostics · 2026Article
- Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Low-Intensity ultrasound for controlled excitation and suppression in rat sciatic nerve.Scientific reports · 2025Article
- Parameter-dependent cell-type specific effects of transcranial focused ultrasound stimulation in an awake head-fixed rodent model.Journal of neural engineering · 2025Article
- Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches.Cells · 2025Review
- Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.Neuron · 2024Article
- Recent advancement of sonogenetics: A promising noninvasive cellular manipulation by ultrasound.Genes & diseases · 2024Review
- Ultrasonic therapies for seizures and drug-resistant epilepsy.Frontiers in neurology · 2023Review
- Low-intensity focused ultrasound, a novel approach to epilepsy treatment in developing countries.Brain and behavior · 2023Article
- General-Purpose Ultrasound Neuromodulation System for Chronic, Closed-Loop Preclinical Studies in Freely Behaving Rodents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Harnessing Ultrasound for Targeting Drug Delivery to the Brain and Breaching the Blood-Brain Tumour Barrier.Pharmaceutics · 2022Review
- Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy.Frontiers in neuroscience · 2022Review
- Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory.Micromachines · 2021Article
- Low-Intensity Focused Ultrasound-Mediated Attenuation of Acute Seizure Activity Based on EEG Brain Functional Connectivity.Brain sciences · 2021Article
- Review on experimental study and clinical application of low-intensity pulsed ultrasound in inflammation.Quantitative imaging in medicine and surgery · 2021Review
- Article
- Numerical Evaluation of the Influence of Skull Heterogeneity on Transcranial Ultrasonic Focusing.Frontiers in neuroscience · 2020Article
- Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive NeuromodulationFrontiers in neuroscience · 2020Article
- An Intelligence EEG Signal Recognition Method via Noise Insensitive TSK Fuzzy System Based on Interclass Competitive Learning.Frontiers in neuroscience · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-intensity pulsed ultrasound stimulation (LIPUS) can inhibit seizures associated with temporal lobe epilepsy (TLE), which is the most common epileptic syndrome in adults and accounts for more than half of the cases of intractable epilepsy. Electroencephalography (EEG) signal analysis is an important method for studying epilepsy. The nonlinear dynamics of epileptic EEG signals can be used as biomarkers for the prediction and diagnosis of epilepsy. However, how ultrasound modulates the nonlinear dynamic characteristics of EEG signals in TLE is still unclear. Here, we used low-intensity pulsed ultrasound to stimulate the CA3 region of kainite (KA)-induced TLE mice, simultaneously recorded local field potentials (LFP) in the stimulation regions before, during, and after LIPUS. The nonlinear characteristics, including complexity, approximate entropy of different frequency bands, and Lyapunov exponent of the LFP, were calculated. Compared with the control group, the experimental group showed that LIPUS inhibited TLE seizure and the complexity, approximate entropy of the delta (0.5-4 Hz) and theta (4-8 Hz) frequency bands, and Lyapunov exponent of the LFP significantly increased in response to ultrasound stimulation. The values before ultrasound stimulation were higher ∼1.87 (complexity), ∼1.39 (approximate entropy of delta frequency bands), ∼1.13 (approximate entropy of theta frequency bands) and ∼1.46 times (Lyapunov exponent) than that after ultrasound stimulation (
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