ArticleJournal of experimental neuroscience2019
Insights Into Traumatic Brain Injury From MRI of Harmonic Brain Motion.
Article in Journal of experimental neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Multiecho Fat-Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement.Magnetic resonance in medicine · 2026Article
- Noninvasive mapping of shear strain predicts the anatomical distribution of mild traumatic brain injury.NeuroImage. Clinical · 2026Article
- MR elastography-based detection of impaired skull-brain mechanical decoupling performance in response to repetitive head impacts.European radiology · 2025Article
- Average Biomechanical Responses of the Human Brain Grouped by Age and Sex.Annals of biomedical engineering · 2025Article
- Effects of anatomy and head motion on spatial patterns of deformation in the human brain.Annals of biomedical engineering · 2025Article
- Full-field, frequency-domain comparison of simulated and measured human brain deformation.Biomechanics and modeling in mechanobiology · 2025Article
- Strain concentration drives the anatomical distribution of injury in acute and chronic traumatic brain injury.bioRxiv : the preprint server for biology · 2024Article
- Effect of Direction and Frequency of Skull Motion on Mechanical Vulnerability of the Human Brain.Journal of biomechanical engineering · 2023Article
- Magnetic Resonance Elastography-Based Technique to Assess the Biomechanics of the Skull-Brain Interface: Repeatability and Age-Sex Characteristics.Journal of neurotrauma · 2023Article
- Rapid, non-invasive,Journal of the Royal Society, Interface · 2023Article
- Comparison of Deformation Patterns Excited in the Human Brain In Vivo by Harmonic and Impulsive Skull Motion.Journal of biomechanical engineering · 2023Article
- Measuring vibrations on a biofidelic brain using ferroelectret nanogenerator.Scientific reports · 2023Article
- Volumetric MRI Findings in Mild Traumatic Brain Injury (mTBI) and Neuropsychological Outcome.Neuropsychology review · 2023Review
- Longitudinal white matter microstructural changes in pediatric mild traumatic brain injury: An A-CAP study.Human brain mapping · 2022Article
- Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography.Medical image analysis · 2022Article
- Quantitative effects of off-resonance related distortion on brain mechanical property estimation with magnetic resonance elastography.NMR in biomedicine · 2022Article
- Displacement voxelization to resolve mesh-image mismatch: Application in deriving dense white matter fiber strains.Computer methods and programs in biomedicine · 2022Article
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- Group characterization of impact-induced,Journal of the Royal Society, Interface · 2021Article
- Natural oscillatory modes of 3D deformation of the human brain in vivo.Journal of biomechanics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Measurements of dynamic deformation of the human brain, induced by external harmonic vibration of the skull, were analyzed to illuminate the mechanics of mild traumatic brain injury (TBI). Shear wave propagation velocity vector fields were obtained to illustrate the role of the skull and stiff internal membranes in transmitting motion to the brain. Relative motion between the cerebrum and cerebellum was quantified to assess the vulnerability of connecting structures. Mechanical deformation was quantified throughout the brain to investigate spatial patterns of strain and axonal stretch. Strain magnitude was generally attenuated as shear waves propagated into interior structures of the brain; this attenuation was greater at higher frequencies. Analysis of shear wave propagation direction indicates that the stiff membranes (falx and tentorium) greatly affect brain deformation during imposed skull motion as they serve as sites for both initiation and reflection of shear waves. Relative motion between the cerebellum and cerebrum was small in comparison with the overall motion of both structures, which suggests that such relative motion might play only a minor role in TBI mechanics. Strain magnitudes and the amount of axonal stretch near the bases of sulci were similar to those in other areas of the cortex, and local strain concentrations at the gray-white matter boundary were not observed. We tentatively conclude that observed differences in neuropathological response in these areas might be due to heterogeneity in the response to mechanical deformation rather than heterogeneity of the deformation itself.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.