ArticleAnnals of neurosciences2018
Comparative Morphometry of the Wisconsin Miniature Swine
Article in Annals of neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The draft genome of the Wisconsin Miniature SwineTM, a valuable biomedical research tool.G3 (Bethesda, Md.) · 2025Article
- Brachial Plexus Anatomy of Sprague Dawley Rat Compared to Human.Journal of brachial plexus and peripheral nerve injury · 2025Article
- Biomechanical evaluation of position and bicortical fixation of anterior lateral vertebral screws in a porcine model.Scientific reports · 2023Article
- Biomechanical Comparison of Different Numbers and Configurations of Cross-Links in Long-Segment Spinal Fixation-An Experimental Study in a Porcine Model.Global spine journal · 2023Article
- Hemodynamic Changes in Response to Hyperacute Spinal Trauma in a Swine Model.Comparative medicine · 2022Article
- Article
- Brachial plexus anatomy in the miniature swine as compared to human.Journal of anatomy · 2022Article
- Biomechanical comparison of pedicle screw fixation strength among three different screw trajectories using single vertebrae and one-level functional spinal unit.Frontiers in bioengineering and biotechnology · 2022Article
- Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain.Annals of neurosciences · 2021Review
- Morphometry of the kangaroo spine and its comparison with human spinal data.Journal of anatomy · 2021Article
- Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsSpine and spinal cord pathologies and associated neuropathic pain are among the most complex medical disorders to treat. While rodent models are widely used in spine and spinal cord research and have provided valuable insight into pathophysiological mechanisms, these models offer limited translatability. Thus, studies in rodent models have not led to the development of clinically effective therapies. More recently, swine has become a favored model for spine research because of the high congruency of the species to humans with respect to spine and spinal cord anatomy, vasculature, and immune responses. However, conventional breeds of swine commonly used in these studies present practical and translational hurdles due to their rapid growth toward weights well above those of humans.
methodsIn the current study, we evaluated the suitability of a human-sized breed of swine developed at the University of Wisconsin-Madison, the Wisconsin Miniature Swine
resultsThe key finding of this study is that WMS spine more closely models the human spine for many of the measured vertebrae parameters, while being similar to conventional swine in respect to the other parameters.
conclusionWMS provides an improvement over conventional swine for use in translational spinal cord injury studies, particularly long-term ones, because of its slower rate of growth and its maximum growth being limited to human weight and size.
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