Lethal clues to cancer-cell vulnerability.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

4 citing papers in PubMed.

1. Biologically relevant integration of transcriptomics profiles from cancer cell lines, patient-derived xenografts, and clinical tumors using deep learning.Science advances · 2025
   Article
2. WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
   Article
3. Integrated cross-study datasets of genetic dependencies in cancer.Nature communications · 2021
   Article
4. Discovering and validating cancer genetic dependencies: approaches and pitfalls.Nature reviews. Genetics · 2020
   Review

Corrections and comments

• Comment on
  Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.2019
• Comment on
  WRN helicase is a synthetic lethal target in microsatellite unstable cancers.2019
• Comment on
  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.2019

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as