ArticleInternational journal of impotence research2020
Anti-fibrotic effect of mycophenolate mofetil on Peyronie's disease experimentally induced with TGF-β.
Article in International journal of impotence research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Stromal Remodeling and Collagen Dynamics under Antifibrotic Conditions in the Rat Prostate.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Intralesional baicalein attenuates fibrosis in a rat model of peyronie's disease by inhibiting TGF-β1/smad signaling.International journal of impotence research · 2026Article
- Assessing kidney outcomes in childhood-onset lupus nephritis: role of National Institutes of Health-modified histological indices.Clinical and experimental pediatrics · 2026Article
- Topohistological alignments of ocular/penile organs.Anatomical science international · 2026Review
- Effects of therapy in experimental models of Peyronie's disease: a scoping review.Sexual medicine · 2024Review
- Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading?Nature reviews. Rheumatology · 2023Article
- European Society of Sexual Medicine consensus statement on the use of animal models for studying Peyronie's disease.Sexual medicine · 2023Article
- Platelet-rich plasma in patients affected with Peyronie's disease.Arab journal of urology · 2023Article
- Sex differences in clinical outcomes and biological profiles in systemic sclerosis-associated interstitial lung disease: a post-hoc analysis of two randomised controlled trials.The Lancet. Rheumatology · 2022Article
- The contribution of the immune system to genitourinary fibrosis.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie's Disease.Biomedicines · 2021Review
- Non-conventional therapies for Peyronie's disease: what is the evidence for efficacy?Translational andrology and urology · 2020Article
- Peyronie's disease: is it genetic or not?Translational andrology and urology · 2020Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to evaluate the histological, histochemical, and stereological changes caused by mycophenolate mofetil (MMF) on the tunica albuginea of rat penises submitted to an injection of transforming growth factor beta (TGF-β) for the induction of Peyronie's disease (PD). Twenty adult male Wistar rats were divided into four groups: Control group; TGF-β group (TGF-β injection); MMF-7d group (treated with MMF 7 days after induction with TGF-β); and MMF-30d group (treated with MMF 30 days after induction with TGF-β). The steorological evaluation included the relative volume of different types of connective fibres of the tunica albuginea. The histochemical analysis revealed the fragmentation and degradation of elastin in the tunica albuginea. This process was partially reversed in the MMF-7d group and a situation very close to normality was observed in the MMF-30d group. In the collagen III/collagen I ratio it was observed increase in this ratio in the TGF-β (59.4 ± 5.53) and MMF-7d (49 ± 18.2) groups and a decrease in the MMF-30d group (28.7 ± 4), approaching normality. The injection of TGF-β promoted fibrotic alterations in the penile tunica albuginea in Wistar rats corresponding to PD. In this model, MMF acts as a regenerating anti-fibrotic agent.
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